tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
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Products Intro:	Product Name:Autogramin-2 CAS:2375541-45-8 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G

Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:Autogramin-2 CAS:2375541-45-8 Purity:96.25% Package:5mg;38USD\|10mg;59USD\|25mg;113USD Remarks:REAGENT;FOR LABORATORY USE ONLY

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Products Intro:	Product Name:Autogramin-2；tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate CAS:2375541-45-8 Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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Products Intro:	CAS:2375541-45-8 Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services

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Products Intro:	Product Name:tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate CAS:2375541-45-8 Purity:95% Package:5mg;25mg;100mg;500mg;1g;5g;10g;25g;50g;100g;250g;500g;kg…

tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate manufacturers

tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Basic information

Product Name:	tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Synonyms:	tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate;187407;Autogramin-2;Thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-2-[[4-(1-methylethoxy)benzoyl]amino]-, 1,1-dimethylethyl ester;Autogramin-2,Inhibitor,inhibit,Autogramin2,Autophagy,Autogramin 2;Autogramin-2, 10 mM in DMSO
CAS:	2375541-45-8
MF:	C21H27N3O4S
MW:	417.52
EINECS:
Product Categories:
Mol File:	2375541-45-8.mol

tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Chemical Properties

density	1.252±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
form	solid
pka	7.59±0.20(Predicted)
color	Off-white
Stability:	Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

MSDS Information

tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Usage And Synthesis

Description	Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A).? Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.
Uses	Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM)[1].
References	1.Laraia et al. (2019), The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis; Chem. Biol., 15 710

tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Preparation Products And Raw materials

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