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| | 2,2',5,5'-Tetrachlorobenzidine Basic information |
| Product Name: | 2,2',5,5'-Tetrachlorobenzidine | | Synonyms: | 4,4'-diamino-5,5',2,2'-tetrachlorobiphenyl;2,2,5,5-TETRACHLORO-4,4-DIAMINOBIPHENYL;2,2,5,5-TETRACHLOROBENZIDINE 98+%;4,4'-DIAMINO-2,2',5,5'-TETRACHLOROBIPHENYL;2,2',5,5'-Tetrachlorobiphenyl-4,4'-diamine;TCB;Benzidine, 2,2',5,5'-tetrachloro-;2,2',5,5'-Tetrachlor | | CAS: | 15721-02-5 | | MF: | C12H8Cl4N2 | | MW: | 322.02 | | EINECS: | 239-815-3 | | Product Categories: | Biphenyl & Diphenyl ether;Intermediates of Dyes and Pigments | | Mol File: | 15721-02-5.mol |  |
| | 2,2',5,5'-Tetrachlorobenzidine Chemical Properties |
| Melting point | 135-140 °C(lit.) | | Boiling point | 477.67°C (rough estimate) | | density | 1.5309 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | -70°C | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 1.58±0.13(Predicted) | | color | Light yellow to Yellow to Orange | | biological source | human | | Water Solubility | water: soluble | | CAS DataBase Reference | 15721-02-5(CAS DataBase Reference) | | IARC | 3 (Vol. 27, Sup 7) 1987 | | EPA Substance Registry System | |
| Hazard Codes | T | | Risk Statements | 61 | | Safety Statements | 53-45 | | WGK Germany | 3 | | RTECS | DD1751000 | | HS Code | 2921.59.8090 |
| | 2,2',5,5'-Tetrachlorobenzidine Usage And Synthesis |
| Uses | PKM1active human has been used in:
- cell-based kinase assay to study the ability of a compound to inhibit the kinase activity of PKM1.
- oxidative stress experiments on PKM2.
- Co-immunoprecipitation (Co-IP) to determine pyruvate kinase M2 (PKM2) as a novel direct binding partner of phosphoserine aminotransferase 1 (PSAT1).
| | Definition | ChEBI: 2,2',5,5'-Tetrachlorobenzidine is a member of biphenyls and a dichlorobenzene. | | Production Methods | 2,2' ,5,5' -Tetrachlorobenzidine is made by the reduction of 2,5-dichloronitrobenzene with zinc dust and sodium hydroxide solution. The subsequent rearrangement is carried out using sulfuric acid or hydrochloric acid. The dihydrochloride melts at 230 ℃. Tetrachlorobenzidine is marketed as the free base and is used to produce yellow pigments. | | Biological Activity | Pyruvate kinase (PK) catalyzes the dephosphorylation of phosphoenolpyruvate(PEP) into pyruvate. It is also involved in glycolysis by releasing ATP.Allosteric effects and intracellular signal transduction regulate the enzymaticactivity of PKM1. PKM1 is involved in several biological processes such asmetabolic reprogramming, and innate and acquired immune response. Itparticipates in protein interactions, protein synthesis, glycolysis, andintranuclear signal transduction. | | Safety Profile | Suspected carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and Cl-. |
| | 2,2',5,5'-Tetrachlorobenzidine Preparation Products And Raw materials |
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