INCYCLINIDE (CMT-3, COL-3)
中文名稱 | INCYCLINIDE (CMT-3, COL-3) |
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中文同義詞 | MMP抑制劑(INCYCLINIDE);化合物INCYCLINIDE;INCYCLINIDE (CMT-3);(4AS,5AR,12AS)-3,10,12,12A-四羥基-1,11-二氧代-1,4,4A,5,5A,6,11,12A-八氫并四苯-2-甲酰胺 |
英文名稱 | Incyclinide |
英文同義詞 | Incyclinide;2-NaphthacenecarboxaMide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4aS,5aR,12aS)-;CMT 3;COL 3;Metastat;NSC 683551;INCYCLINIDE (CMT-3, COL-3);Incyclinide (CMT-3) |
CAS號 | 15866-90-7 |
分子式 | C19H17NO7 |
分子量 | 371.34 |
EINECS號 | |
相關類別 | 細胞生物學試劑 |
Mol文件 | 15866-90-7.mol |
結(jié)構(gòu)式 |
INCYCLINIDE (CMT-3, COL-3) 性質(zhì)
熔點 | 228-231 °C |
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沸點 | 752.8±60.0 °C(Predicted) |
密度 | 1.70±0.1 g/cm3(Predicted) |
儲存條件 | Store at -20°C |
溶解度 | DMSO:100.0(最大濃度 mg/mL);269.29(最大濃度 mM) |
形態(tài) | 固體 |
酸度系數(shù)(pKa) | 4.50±1.00(Predicted) |
顏色 | 淺黃至黃色 |
Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%.
Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix.
安全信息
更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2024/11/08 | HY-13648 | INCYCLINIDE (CMT-3, COL-3) Incyclinide | 15866-90-7 | 1mg | 780元 |
2024/11/08 | HY-13648 | INCYCLINIDE (CMT-3, COL-3) Incyclinide | 15866-90-7 | 5mg | 1200元 |