4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one manufacturers
- Nexinhib20
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- $78.00 / 1mg
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2024-10-24
- CAS:331949-35-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one Basic information |
| Product Name: | 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one | | Synonyms: | 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one;1-Penten-3-one, 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-;Nexinhib20,Nexinhib-20 | | CAS: | 331949-35-0 | | MF: | C15H16N4O3 | | MW: | 300.31 | | EINECS: | | | Product Categories: | | | Mol File: | 331949-35-0.mol |  |
| | 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one Chemical Properties |
| Boiling point | 508.2±60.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 30 mg/ml; Ethanol: 15 mg/ml | | form | A crystalline solid | | pka | 1.50±0.12(Predicted) | | color | White to yellow |
| | 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one Usage And Synthesis |
| Uses | Nexinhib 20 is an inhibitor of Rab27a-JFC1 interaction, it inhibits the neutrophil exocytosis and inflammation | | Biological Activity | Nexinhib20 (neutrophil exocytosis inhibitor 20) is a potent inhibitor of the interaction between the small GTPase Rab27a and its effector JFC1 (synaptotagmin-like protein1). Nexinhib20 inhibits exocytosis of azurophilic granules in human neutrophils without affecting other important innate immune responses including phagocytosis and neutrophil extracellular trap production.', 'Nexinhib20 prevents the expression of cytochrome b558 in the plasma membrane. It modulates vesicular trafficking and neutrophil activities. Nexinhib20 reduces the systemic inflammation, mediated by neutrophils. | | storage | Store at +4°C |
| | 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one Preparation Products And Raw materials |
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