| Company Name: |
Zhengzhou Granlen Sciences, ltd.
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| Tel: |
0371-85513397 +86-18610099868; |
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info@granlen.com |
| Products Intro: |
Product Name:2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluoro inosine 3’-CED phosphoramidite
CAS:2245842-16-2
Purity: 95% HPLC Package:根據(jù)客戶需要包裝 Remarks:GL105116
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| Company Name: |
Hefei Stongbio Co.,Ltd.
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| Tel: |
15555170917 |
| Email: |
sales@stongbio.com |
| Products Intro: |
CAS:2245842-16-2
Purity:>=98% Package:1g;100g;1000g
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INDEX NAME NOT YET ASSIGNED manufacturers
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| Product Name: | INDEX NAME NOT YET ASSIGNED | | Synonyms: | 2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluoro inosine 3’-CED phosphoramidite;(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluoroinosine3’-CEDphosphoramidite;2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite;5'-O-(4，4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyinosine-3'-cyanoethyl phosphoramidite;5’-O-(4,4-Dimethoxytrityl)-2’-fluoro-2’-deoxy inosine-3’-CED phosphoramidite | | CAS: | 2245842-16-2 | | MF: | C40H46FN6O7P | | MW: | 772.82 | | EINECS: | | | Product Categories: | | | Mol File: | 2245842-16-2.mol |  |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| Boiling point | 840.2±75.0 °C(Predicted) | | pka | 3.45±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Uses | 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2]. | | References | [1] Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. DOI:10.1096/fj.00-0299com
[2] Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. DOI:10.1203/00006450-198802000-00001 |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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