136941-70-3
| 中文名稱 | 136941-70-3 |
|---|---|
| 中文同義詞 | 化合物 T10101;鈣離子通道調(diào)節(jié)劑1;鈣離子通道調(diào)節(jié)劑1,10 MM DMSO 溶液 |
| 英文名稱 | 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide |
| 英文同義詞 | 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide;Calcium channel-modulator-1;3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-[3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl] 5-methyl ester;Calcium channelmodulator1,Calcium channel modulator 1;Calcium channel-modulator-1, 10 mM in DMSO |
| CAS號 | 136941-70-3 |
| 分子式 | C26H24Cl2N2O7S |
| 分子量 | 579.44896 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 136941-70-3.mol |
| 結構式 |  |
136941-70-3 性質(zhì)
| 沸點 | 721.2±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.427±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 2.62±0.70(Predicted) |
| 顏色 | 白色至米白色 |
Calcium channel-modulator-1是鈣離子通道 (calcium channel) 調(diào)節(jié)劑，阻塞主動脈收縮的 IC50 值為0.8 μM。
IC50: 0.8 μM (Aortic contraction)
Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-U00135 | Calcium channel-modulator-1 | 136941-70-3 | 1 mg | 1530元 |
| 2025/05/22 | HY-U00135 | 136941-70-3 Calcium channel-modulator-1 | 136941-70-3 | 5 mg | 2970元 |