- CID5721353
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- $46.00 / 5mg
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2024-11-17
- CAS:301356-95-6
- Min. Order:
- Purity: 99.2%
- Supply Ability: 10g
- CID5721353
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- $1.00 / 1KG
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2019-12-26
- CAS:301356-95-6
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
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| | CID5721353 Basic information |
| Product Name: | CID5721353 | | Synonyms: | CID5721353;CID5721353, BCL6 inhibitor;BCL6 inhibitor(CID5721353);CID5721353 BDL6 inhribitor;CID-5721353;CID 5721353;79-6 (CID5721353， BCL6 inhibitor);CID 5721353;CID-5721353;CID 5721353;2-(5-(5-bromo-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)succinic acid | | CAS: | 301356-95-6 | | MF: | C15H9BrN2O6S2 | | MW: | 457.28 | | EINECS: | | | Product Categories: | API | | Mol File: | 301356-95-6.mol |  |
| | CID5721353 Chemical Properties |
| density | 2.06±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 3.02±0.23(Predicted) | | color | Light brown to brown |
| | CID5721353 Usage And Synthesis |
| Description | CID-5721353 is an inhibitor of the transcriptional repressor B cell lymphoma 6 (Bcl-6; Ki = 147 μM). It is selective for Bcl-6 over Kaiso, hypermethylated in cancer 1 (HIC1), and promyelocytic leukemia zinc finger (PLZF) at 50 μM. CID-5721353 is cytotoxic against Bcl-6-dependent SU-DLH-6, SU-DLH-4, Farage, OCI-LY7, OCI-LY1, and OCI-LY10 diffuse large B cell lymphoma (DLBCL) cells (GI50s = 0.024-0.936 mM) but not Bcl-6-independent Toledo or OCI-LY4 DLBCL cells (GI50 = >15 mM for both). It increases expression of the Bcl-6 target genes ATR, TP53, CD69, p21, and CD44 in SU-DLH-6 and SU-DHL-4 cells when used at a concentration of 50 μM. CID-5721353 (50 mg/kg) reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models. |
| | CID5721353 Preparation Products And Raw materials |
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