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SR 58611A

SR 58611A Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Amibegron hydrochloride;SR 58611A
CAS:121524-09-2
Purity:98.00% Package:5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:Amibegron hydrochloride
CAS:121524-09-2
Package:100mg;1830USD|50mg;1210USD|25mg;931USD
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:SR 58611A hydrochloride
CAS:121524-09-2
Purity:>=98%(HPLC) Package:$203.9/10mg;$834.9/50mg;Bulk package Remarks:98%(HPLC)
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:Amibegron hydrochloride
CAS:121524-09-2
Package:100mg;1830USD|50mg;1210USD|25mg;931USD
Company Name:   
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:SR 58611A;[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]aMino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yaceticacidethylesterhydrochloride
CAS:121524-09-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g

SR 58611A manufacturers

SR 58611A Basic information
Product Name:SR 58611A
Synonyms:SR 58611A hydrochloride;SR 58611A;[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yaceticacidethylesterhydrochloride;Amibegron hydrochloride;Acetic acid, [[(7S)?-?7-?[[(2R)?-?2-?(3-?chlorophenyl)?-?2-?hydroxyethyl]?amino]?-?5,?6,?7,?8-?tetrahydro-?2-?naphthalenyl]?oxy]?-?, ethyl ester, hydrochloride (1:1);Amibegron HCl;Amibegron hydrochloride(SR 58611A)
CAS:121524-09-2
MF:C22H27Cl2NO4
MW:440.36
EINECS:
Product Categories:
Mol File:121524-09-2.mol
SR 58611A Structure
SR 58611A Chemical Properties
storage temp. -20°C
solubility DMSO: soluble20mg/mL, clear
form powder
color white to beige
optical activity[α]/D -75 to -95°, c = 0.5 in methanol
Safety Information
Hazard Codes N
Risk Statements 50/53
Safety Statements 61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
MSDS Information
SR 58611A Usage And Synthesis
UsesSR 58611A is a selective β3-adrenergic receptor agonist with anxiolytic and antidepressant properties (1,2). SR 58611A is blood brain barrier permeable.
Biochem/physiol ActionsSR58611A is a potent, specific b3 adrenergic receptor agonist. The EC50 for reduction of β3-mediated spontaneous motility in rat distal colon sections is 3.5 nM. Minimal anti-depressant efficacious doses for SR58611A are 0.1-0.3 mpk in rodent models.
in vivo

Amibegron hydrochloride (SR 58611A, 0.1 to 0.3 mg/kg, i.p.) potentiates the toxicity produced by yohimbine in mice. Amibegron hydrochloride (0.6 and 2 mg/kg, i.p.) is also active in the learned helplessness model of antidepressant-like activity in rats. However, Amibegron hydrochloride exhibits no effect on the spontaneous locomotor activity of mice at up to 10 mg/kg and of rats at up tp 30 mg/kg[2]. Amibegron hydrochloride (3 and 10 mg/kg, p.o.) increases the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas such as cortex, hippocampus, hypothalamus, striatum. In addition, Amibegron hydrochloride (10 mg/kg, p.o.) promotes the release of 5-HT in rat prefrontal cortex. Systemic (3 mg/kg, i.v.) or chronic administration of SR58611A (10 mg/kg, p.o.) does not affect the activity of serotonergic neurons in the rat dorsal raphe nucleus[3].

IC 50β adrenergic receptor
storageDesiccate at RT
SR 58611A Preparation Products And Raw materials
Tag:SR 58611A(121524-09-2) Related Product Information

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