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Product Name:SR 58611A;[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]aMino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yaceticacidethylesterhydrochloride
CAS:121524-09-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | SR 58611A Basic information |
| Product Name: | SR 58611A | | Synonyms: | SR 58611A hydrochloride;SR 58611A;[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yaceticacidethylesterhydrochloride;Amibegron hydrochloride;Acetic acid, [[(7S)?-?7-?[[(2R)?-?2-?(3-?chlorophenyl)?-?2-?hydroxyethyl]?amino]?-?5,?6,?7,?8-?tetrahydro-?2-?naphthalenyl]?oxy]?-?, ethyl ester, hydrochloride (1:1);Amibegron HCl;Amibegron hydrochloride（SR 58611A） | | CAS: | 121524-09-2 | | MF: | C22H27Cl2NO4 | | MW: | 440.36 | | EINECS: | | | Product Categories: | | | Mol File: | 121524-09-2.mol |  |
| | SR 58611A Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | color | white to beige | | optical activity | [α]/D -75 to -95°, c = 0.5 in methanol |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| | SR 58611A Usage And Synthesis |
| Uses | SR 58611A is a selective β3-adrenergic receptor agonist with anxiolytic and antidepressant properties (1,2). SR 58611A is blood brain barrier permeable. | | Biochem/physiol Actions | SR58611A is a potent, specific b3 adrenergic receptor agonist. The EC50 for reduction of β3-mediated spontaneous motility in rat distal colon sections is 3.5 nM. Minimal anti-depressant efficacious doses for SR58611A are 0.1-0.3 mpk in rodent models. | | in vivo | Amibegron hydrochloride (SR 58611A, 0.1 to 0.3 mg/kg, i.p.) potentiates the toxicity produced by yohimbine in mice. Amibegron hydrochloride (0.6 and 2 mg/kg, i.p.) is also active in the learned helplessness model of antidepressant-like activity in rats. However, Amibegron hydrochloride exhibits no effect on the spontaneous locomotor activity of mice at up to 10 mg/kg and of rats at up tp 30 mg/kg[2]. Amibegron hydrochloride (3 and 10 mg/kg, p.o.) increases the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas such as cortex, hippocampus, hypothalamus, striatum. In addition, Amibegron hydrochloride (10 mg/kg, p.o.) promotes the release of 5-HT in rat prefrontal cortex. Systemic (3 mg/kg, i.v.) or chronic administration of SR58611A (10 mg/kg, p.o.) does not affect the activity of serotonergic neurons in the rat dorsal raphe nucleus[3]. | | IC 50 | β adrenergic receptor | | storage | Desiccate at RT |
| | SR 58611A Preparation Products And Raw materials |
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