| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:ARUK3001185
CAS:2411969-39-4
Purity:98% Package:1mg;2mg;5mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:ARUK3001185
CAS:2411969-39-4
Package:2mg/RMB 991;5mg/RMB 1660;25mg/RMB 6190
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:ARUK3001185
|
1H-1,2,3-Triazole, 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]- manufacturers
- ARUK3001185
-
- $95.00 / 2mg
-
2024-11-19
- CAS:2411969-39-4
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | 1H-1,2,3-Triazole, 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]- Basic information |
| | 1H-1,2,3-Triazole, 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]- Chemical Properties |
| Boiling point | 359.6±52.0 °C(Predicted) | | density | 1.62±0.1 g/cm3(Predicted) | | storage temp. | -10 to -25°C | | solubility | DMSO: 5 mg/ml | | form | A crystalline solid | | pka | -0.96±0.70(Predicted) | | color | Off-white to pink |
| | 1H-1,2,3-Triazole, 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]- Usage And Synthesis |
| Description | ARUK3001185 is an inhibitor of palmitoleoyl-protein carboxylesterase NOTUM (IC50 = 6.7 nM), an enzyme involved in the deacylation of Wnt.1 It is selective for NOTUM over a panel of 39 serine hydrolases and 485 kinases, including casein kinase 1 (CK1) and glycogen synthase kinase 3 (GSK3), at 10 μM and a panel of 47 receptors, ion channels, transporters, and enzymes at 30 μM, but does inhibit the serotonin (5-HT) receptor subtype 5-HT3A, α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs), and monoamine oxidase A (MAO-A; IC50s = 4.5, 10, and 28 μM, respectively). ARUK3001185 prevents NOTUM-induced decreases in Wnt3a signaling in a cell-based reporter assay (EC50 = 110 nM). | | References | 1. Willis, N.J., Mahy, W., Sipthorp, J., et al. Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme notum by optimization of a crystallographic fragment hit J. Med. Chem. 65(10),7212-7230(2122). |
| | 1H-1,2,3-Triazole, 1-[2,4-dichloro-3-(trifluoromethyl)phenyl]- Preparation Products And Raw materials |
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