| Company Name: |
JW & Y Pharmlab Co., Ltd.
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| Tel: |
021-64340559 13651849907; |
| Email: |
xinyu_shi@jwypharmlab.com.cn |
| Products Intro: |
Product Name:(S)-3-(2-Amino-propyl)-phenol
CAS:18840-47-6
Purity:97% Package:mg;g;kg等可分裝
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| Company Name: |
Bejing Famous Pharmaceutical Technology Co., Ltd.
|
| Tel: |
13331045123 |
| Email: |
1963319514@qq.com |
| Products Intro: |
Product Name:(S)-3-(2-aminopropyl)phenol
CAS:18840-47-6
Purity:97% Package:1g;5g;10g;25g;50g;100g;250g;500g;1kg;5kg;10kg;25kg;50kg;100kg;250kg;500kg
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| | Gepefrine Basic information |
| Product Name: | Gepefrine | | Synonyms: | Gepefrine [inn];Unii-V51rrx51vh;(S)-3-(2-AMINOPROPYL)PHENOL;Gepefrine;Phenol, 3-[(2S)-2-aminopropyl]-;Metaraminol Bitartrate Impurity 63;Rivastigmine Impurity 25;Metaramine bitartrate Impurity 63 | | CAS: | 18840-47-6 | | MF: | C9H13NO | | MW: | 151.21 | | EINECS: | | | Product Categories: | | | Mol File: | 18840-47-6.mol |  |
| | Gepefrine Chemical Properties |
| Melting point | 155-158° | | alpha | D25 +31.8° (c = 2 in methanol) | | Boiling point | 281.0±15.0 °C(Predicted) | | density | 1.070±0.06 g/cm3(Predicted) | | pka | 9.86±0.10(Predicted) | | InChI | InChI=1S/C9H13NO/c1-7(10)5-8-3-2-4-9(11)6-8/h2-4,6-7,11H,5,10H2,1H3/t7-/m0/s1 | | InChIKey | WTDGMHYYGNJEKQ-ZETCQYMHSA-N | | SMILES | C1(O)=CC=CC(C[C@@H](N)C)=C1 |
| | Gepefrine Usage And Synthesis |
| Originator | Pressionorm,Helopharm,W. Germany,1981 | | Manufacturing Process | Hydrolysis of D-(+)-1-(3-rnethoxyphenyl)-2-aminopropane: 2.42 mols (40 g)
of the compound are dissolved in 6N hydrochloric acid in a bomb tube
consisting of stainless steel and having a capacity of 500 ml. Hydrogen
chloride gas is passed into the ice-cooled solution until this is saturated, The
solution is then heated to 130°C for 2 hours in an air bath. After cooling and
driving off the hydrochloric acid at a slightly elevated temperature, the
hydrochloride of the 3-hydroxyphenyl derivative is present in the form of a
yellowish syrup.
The free base can be liberated from the hydrochloride by extracting a butanol
solution of the hydrochloride several times with sodium bicarbonate solution.
After recrystallization from isopropanol/ligroin, the yield of D-(+)-1-(3-
hydroxyphenyl)-2-aminopropane amounts to 33.0 g, corresponding to 90.1%
of theory relative to the D-form. Melting point = 152°C to 154°C. | | Therapeutic Function | Antihypotensive |
| | Gepefrine Preparation Products And Raw materials |
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