| Company Name: |
Shanghai kcmd Bio Pharmaceutical Co., Ltd Gold
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| Tel: |
13818960522 |
| Email: |
525712405@qq.com |
| Products Intro: |
Product Name:Apostain-1
CAS:2559703-06-7
Purity:98% Package:1g;10g;100g;500g;1KG;5KG;25KG
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
|
| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Apostatin-1
CAS:2559703-06-7
Purity:98% HPLC LCMS Package:100mg;1g
|
Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- manufacturers
- Apostatin-1
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- $31.00 / 1mg
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2024-11-19
- CAS:2559703-06-7
- Min. Order:
- Purity: 100%
- Supply Ability: 10g
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| | Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- Basic information |
| Product Name: | Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- | | Synonyms: | Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]-;N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide;Apostain-1;Apostatin 1,TRADD,Apostatin-1,Beclin1,RIPK,Autophagy,SH-SY5Y,Receptor-interacting protein kinases,Apoptosis,Apostatin1,HT-29,Jurkat cells,RIP kinase,inhibit,beclin 1,Inhibitor,Atg6,Apt1,Apt 1,Necroptosis,inflammatory responses,HeLa,RIPK1 | | CAS: | 2559703-06-7 | | MF: | C19H27N3OS | | MW: | 345.51 | | EINECS: | | | Product Categories: | | | Mol File: | 2559703-06-7.mol | ![Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- Structure](CAS/20211123/GIF/2559703-06-7.gif) |
| | Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- Chemical Properties |
| density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 83.33 mg/mL (241.19 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 80°C) | | pka | 13.99±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- Usage And Synthesis |
| Biological Activity | Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin[1].
Apostatin-1 inhibits Velcade (Bortezomib, 0)-induced apoptosis and RIPK1-dependent apoptosis (RDA) and necroptosis, with an IC50 of 0.97 μM[1].Apostatin-1 (10 μM, 6 h) effectively induces autophagy and the degradation of long-lived proteins[1].
Apostatin-1 (20 mg/kg, IP, once) inhibits inflammatory responses, and increases survival of systemic inflammation mouse model[1]. | | References | [1]. Xu D, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587(7832):133-138. |
| | Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- Preparation Products And Raw materials |
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