鹽酸螺普利
| 中文名稱 | 鹽酸螺普利 |
|---|---|
| 中文同義詞 | 鹽酸螺普利;鹽酸螺普利溶液, 100PPM;鹽酸螺普利溶液,1000PPM;鹽酸螺普利一水合物 EP標(biāo)準(zhǔn)品;螺普利系統(tǒng)適用性 EP標(biāo)準(zhǔn)品;化合物 SPIRAPRIL HYDROCHLORIDE;螺普利/用于系統(tǒng)適用性試驗(yàn)/A1A;螺普利鹽酸鹽 |
| 英文名稱 | Spirapril hydrochloride |
| 英文同義詞 | Renormax;Renpress;Sandopril;TI 211-950;1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, monohydrochloride, (8S-(7(R*(R*)),8R*))-;Spirapril HCl;Unii-occ25lm897;Spirapril hydrochloride |
| CAS號(hào) | 94841-17-5 |
| 分子式 | C22H30N2O5S2.HCl |
| 分子量 | 503.07 |
| EINECS號(hào) | |
| 相關(guān)類別 | API;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol文件 | 94841-17-5.mol |
| 結(jié)構(gòu)式 |  |
鹽酸螺普利 性質(zhì)
| 熔點(diǎn) | 192-1940C (dec.) |
|---|---|
| 比旋光度 | D26 -11.2° (c = 0.4 in ethanol) |
| 儲(chǔ)存條件 | -20°C Freezer |
| 溶解度 | 極微溶于水，溶于甲醇，微溶于乙腈，幾乎不溶于二氯甲烷。 |
| 形態(tài) | 固體 |
| 顏色 | 白色至類白色 |
| 穩(wěn)定性 | 吸濕性 |
Spirapril (SCH 33844) hydrochloride 是一種有效的血管緊張素轉(zhuǎn)換酶 (ACE) 抑制劑，具有降壓作用。Spirapril hydrochloride 競(jìng)爭(zhēng)性地與 ACE 結(jié)合，阻止血管緊張素I向血管緊張素 II 的轉(zhuǎn)化。Spirapril hydrochloride 是螺普利拉的一種口服活性前藥，可用于高血壓、充血性心力衰竭的研究。
IC50: angiotensin converting enzyme
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.
| Animal Model: | TGM123 mice (expressing a rat angiotensinogen transgene) and TLM ( lacking the angiotensinogen gene) mice |
| Dosage: | 10 mg/kg |
| Administration: | Feeding needle; 10 mg/kg; 3 weeks |
| Result: | Alter voluntary alcohol consumption in animals. Crossed the blood-brain barrier and may influences alcohol consumption mainly by decreasing central angiotensin II (AII) levels. |
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-A0230A | 鹽酸螺普利 Spirapril hydrochloride | 94841-17-5 | 1 mg | 1409元 |
| 2025/02/08 | HY-A0230A | 鹽酸螺普利 Spirapril hydrochloride | 94841-17-5 | 5 mg | 3100元 |