- Anipamil
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- $1520.00 / 25mg
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2024-10-24
- CAS:83200-10-6
- Min. Order:
- Purity:
- Supply Ability: 10g
- Anipamil
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- $0.00 / 1KG
-
2020-05-12
- CAS:83200-10-6
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 500 MT
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| | anipamil Basic information |
| Product Name: | anipamil | | Synonyms: | anipamil;2-Dodecyl-5-[3-methoxyphenethyl(methyl)amino]-2-(3-methoxyphenyl)pentanenitrile;2-(3-methoxyphenyl)-2-[3-[2-(3-methoxyphenyl)ethyl-methylamino]propyl]tetradecanenitrile;Benzeneacetonitrile, α-dodecyl-3-methoxy-α-[3-[[2-(3-methoxyphenyl)ethyl]methylamino]propyl]-;anipamil USP/EP/BP;Anipamilum [Latin] | | CAS: | 83200-10-6 | | MF: | C34H52N2O2 | | MW: | 520.79 | | EINECS: | 2802135 | | Product Categories: | | | Mol File: | 83200-10-6.mol |  |
| | anipamil Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Acetone (Slightly), Methanol (Slightly) | | form | Thick Oil to Gel | | color | Pale Yellow |
| | anipamil Usage And Synthesis |
| Originator | Anipamil,Onbio Inc. | | Uses | A long-acting analog of Verapamil (V125000) with antiarrhythmic and antihypertensive activity. | | Manufacturing Process | 1,7-Bis-(3-ethoxyphenyl)-3-methylaza-7-cyano-nonadecane:
0.06 mole of 1-cyano-1-(3-methoxyphenyl)tridecane (prepared by phase
transfer-catalyzed alkylation of 3-methoxyphenylacetonitrile with 1-
bromododecane) and 0.06 mole of 1-chloro-4-methylaza-6-(3-
methoxyphenyl)hexane [prepared from N-methyl-β-(3-
methoxyphenyl)ethylamine and 1-bromo-3-chloropropane by a method similar
to that described in Arzneim.-Forsch. 28 (II) (1978), 2048] were dissolved in
100 ml of dry toluene in a three-necked flask provided with a stirrer, dropping
funnel, reflux condenser and thermometer. 9.3 g (0.07 mole) of a 30%
strength suspension of sodium amide in toluene were then added dropwise at
from 100° to 110°C, with stirring, and stirring was continued under reflux for
a further 90 minutes.
The resulting reaction solution was poured into 200 ml of ice water, and the
toluene phase was separated off and washed twice with water. The required
amount of hydrochloric acid was added to the toluene solution, the toluene
was distilled off under reduced pressure and the residue, which remained was
recrystallized from acetone to give 1,7-bis-(2-methoxyphenyl)-3-methylaza-7-
cyanononadecane hydrochloride or α-dodecyl-3-methoxy-α-[3-[[2-(3-
methoxyphenyl)ethyl]methylamino]propyl]benzene-acetonitrile (anipamil);
MP: 60°-69.5°C. | | Therapeutic Function | Coronary vasodilator, Antihypertensive |
| | anipamil Preparation Products And Raw materials |
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