| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:BMS-665053
CAS:1173435-64-7
Purity:>=98% (HPLC) Package:5MG Remarks:BM0033-5MG
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:BMS-665053 >=98% (HPLC)
CAS:1173435-64-7
Purity:NULL Package:25mg;5mg Remarks:NULL
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BMS-665053
CAS:1173435-64-7
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
|
BMS 665053 manufacturers
- BMS-665053
-
- $1520.00 / 25mg
-
2024-10-24
- CAS:1173435-64-7
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | BMS 665053 Basic information |
| Product Name: | BMS 665053 | | Synonyms: | BMS 665053;5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[2,6-dichloro-4-(difluoromethoxy)anilino]pyrazin-2-one;2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropylethyl]-3-[[2,6-dichloro-4-(difluoromethoxy)phenyl]amino]-;BMS-665053 >=98% (HPLC) | | CAS: | 1173435-64-7 | | MF: | C16H14Cl3F2N3O2 | | MW: | 424.66 | | EINECS: | | | Product Categories: | | | Mol File: | 1173435-64-7.mol |  |
| | BMS 665053 Chemical Properties |
| storage temp. | room temp | | solubility | DMSO: 20mg/mL, clear | | form | powder | | color | white to light brown | | optical activity | [α]/D +16 to +21°, c = 0.4 in chloroform-d |
| | BMS 665053 Usage And Synthesis |
| Biochem/physiol Actions | BMS-665053 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 10 μM against 150 pM ovine CRF in binding assay). BMS-665053 exhibits anxiolytic efficacy in a defensive withdrawal anxiety test in rats in vivo (10 mg/kg p.o.) with good oral bioavailability (F = 52%). |
| | BMS 665053 Preparation Products And Raw materials |
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