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| 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Basic information |
Product Name: | 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester | Synonyms: | 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester;Fxr 450;Turofexorate isopropyl;Turofexorate isopropyl [usan];Unii-S6kdm312I5;Way 362450;isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate;isopropyl 3-(3,4-difluorobenzoyl)-1,1-diMethyl-1,2,3,6-tetrahydr | CAS: | 629664-81-9 | MF: | C25H24F2N2O3 | MW: | 438.47 | EINECS: | | Product Categories: | Inhibitors;A farnesoid X receptor (FXR) agonist . | Mol File: | 629664-81-9.mol | |
| 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Chemical Properties |
Boiling point | 617.3±55.0 °C(Predicted) | density | 1.275 | storage temp. | room temp | solubility | DMSO : 25 mg/mL (57.02 mM; Need ultrasonic) | form | powder | pka | 16.49±0.60(Predicted) | color | white to beige |
| 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Usage And Synthesis |
Definition | ChEBI: Turofexorate isopropyl is a member of indoles. | Biochem/physiol Actions | WAY-362450 is a potent and selective Farnesoid X receptor (FXR) agonist that lowers total plasma cholesterol (all lipoprotein species). WAY-362450 reduced the levels of high-density lipoprotein cholesterol (HDLc) in Cynomolgus monkeys, mice and hamsters. Apparently HDL lowering is achieved through increased transhepatic cholesterol efflux. |
| 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester Preparation Products And Raw materials |
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