- kukoamine A
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- $8.00 / 1KG
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2020-02-21
- CAS:75288-96-9
- Min. Order: 1g
- Purity: ＞98% HPLC
- Supply Ability: kg--ton
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| | kukoamine A Basic information |
| Product Name: | kukoamine A | | Synonyms: | kukoamine A;1,14-Bis(dihydrocaffeoyl)spermidine;N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide];N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide];N1,N12-Bis(dihydrocaffeoyl) spermine;Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-;N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide);NSC 5398 | | CAS: | 75288-96-9 | | MF: | C28H42N4O6 | | MW: | 530.66 | | EINECS: | | | Product Categories: | | | Mol File: | 75288-96-9.mol |  |
| | kukoamine A Chemical Properties |
| Boiling point | 872.1±65.0 °C(Predicted) | | density | 1.213±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | pka | 9.48±0.10(Predicted) | | color | Off-white to yellow | | CAS DataBase Reference | 75288-96-9 |
| | kukoamine A Usage And Synthesis |
| Description | Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A (5-20 μg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner. It halts the cell cycle at the G0/G1 phase and induces apoptosis when used at concentrations of 60 and 80 μg/ml. Kukoamine A (20 and 40 μM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury. It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury. It also selectively inhibits trypanothione reductase (Ki = 1.8 μM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (Ki = >10 mM). | | Occurrence | The root bark of Lychium chinense yields this alkaloid. Kukoamine A
possesses hypotensive activity inducing hypotension in rats at a dose of 5 mg/kg when
given intravenously. | | Uses | Kukoamine A is a neuroprotective agent which is used to prevent the loss of dopaminergic neurons in substantia nigra. | | Definition | ChEBI: Kukoamine A is an amine. |
| | kukoamine A Preparation Products And Raw materials |
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