HYMENIALDISINE ANALOGUE #1 基本信息
| 中文名稱 | HYMENIALDISINE ANALOGUE #1 |
|---|---|
| 中文同義詞 | 化合物 HYMENIALDISINE ANALOGUE #1 |
| 英文名稱 | HYMENIALDISINE ANALOGUE #1 |
| 英文同義詞 | HYMENIALDISINE ANALOGUE #1;5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-b]indol-1-one;5-(2-Amino-5-oxo-1,5-dihydroimidazol-4-ylidene)-3,4,5,10-tetrahydro-2H-azepino[3,4-β]indol-1-one;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro- |
| CAS號 | 693222-51-4 |
| 分子式 | C15H13N5O2 |
| 分子量 | 295.3 |
| EINECS號 | |
| 相關(guān)類別 | Protein Kinase Inhibitors and Activators;Tyrosine Kinase Inhibitors |
| Mol文件 | 693222-51-4.mol |
| 結(jié)構(gòu)式 |  |
HYMENIALDISINE ANALOGUE #1 性質(zhì)
| 密度 | 1.73±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | -20°C Freezer |
| 溶解度 | 二甲基亞砜（微溶） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 14.41±0.20(Predicted) |
| 顏色 | 淺黃色至厚黃色 |
| CAS 數(shù)據(jù)庫 | 693222-51-4 |
用途
The indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar con centrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymeniald isine.