| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:MBX2546
CAS:695160-12-4
Purity:>=98% (HPLC) Package:5MG Remarks:SML2151-5MG
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:MBX2546
CAS:695160-12-4
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
|
MBX2546 manufacturers
- MBX2546
-
- $1520.00 / 25mg
-
2024-10-28
- CAS:695160-12-4
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | MBX2546 Basic information |
| Product Name: | MBX2546 | | Synonyms: | MBX2546;Acetamide, N-(3,5-dimethylphenyl)-2-[(2-methyl-5-nitrophenyl)(methylsulfonyl)amino]- | | CAS: | 695160-12-4 | | MF: | C18H21N3O5S | | MW: | 391.44 | | EINECS: | | | Product Categories: | | | Mol File: | 695160-12-4.mol |  |
| | MBX2546 Chemical Properties |
| density | 1.365±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | pka | 12.93±0.70(Predicted) | | form | powder | | color | white to beige |
| | MBX2546 Usage And Synthesis |
| Biochem/physiol Actions | MBX2546 is a non-cytotoxic (CC50 >100 μM; 283T) molecule that inhibits against influenza hemagglutinin- (HA-) mediated viral entry (IC90 = 5.7 μM against HIV/HA(H5) entry in 293T culture vs. IC90 >100 μM, 98.2 μM, and >85 μM against HIV/LASV-GP, HIV/EBOV-GP, HIV/VSV-G, respectively) by targeting group 1 HA-specific conformational epitope in the HA stem loop region. MBX2546 is shown to inhibit influenza A strains A/PR/8/34 (H1N1) and A/Florida/21/2008 (H1N1-H275Ψ) (oseltamivir-resistant strain), A/California/10/2009/H1N1, as well as high pathogenic avian influenza (HPAI) strain A/Hong Kong/H5N1 (IC50 = 0.3, 5.8, 0.55-1.5, and 3.6 μM, respectively), but not A/Texas/12/2007 (H3N2), A/Perth/16/2009 (H3N2), A/Victoria/3/75 (H3N2), A/Panama/2007/99 (H3N2), A/Sydney/05/97 (H3N2), A/California/7/04 (H3N2), A/Wyoming/03/2003 (H3N2), or influenza B strain B/Florida/4/2006 in MDCK cultures. |
| | MBX2546 Preparation Products And Raw materials |
|