2-氨基-2-去甲菠烷羧酸
| 中文名稱 | 2-氨基-2-去甲菠烷羧酸 |
|---|---|
| 中文同義詞 | 2-氨基-2-去甲菠烷羧酸;2-氨基-2-二甲基降莰烷;2-氨基雙環(huán)[2.2.1]庚烷-2-羧酸;2-氨基二環(huán)[2.2.1]庚烷-2-羧酸;2-氨基-2-去甲冰片羧酸 |
| 英文名稱 | 2-AMINO-2-NORBORNANECARBOXYLIC ACID |
| 英文同義詞 | 2-AMINO-2-NORBORNANECARBOXYLIC ACID;2-AMINOBICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;BCH;2-AMINO-2-NORBORNANECARBOXYLIC ACID, 98% , MIXTURE OF ISOMERS;2-Amino-2-carboxy-bicyclo-2,2,1-heptane;2-Aminonorbornane-2-carboxylic acid;B-Bch;Bicyclo(2.2.1)heptane-2-carboxylic acid, 2-amino- |
| CAS號 | 20448-79-7 |
| 分子式 | C8H13NO2 |
| 分子量 | 155.19 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 20448-79-7.mol |
| 結(jié)構(gòu)式 |  |
2-氨基-2-去甲菠烷羧酸 性質(zhì)
| 熔點(diǎn) | >300 °C(lit.) |
|---|---|
| 沸點(diǎn) | 295.5±23.0 °C(Predicted) |
| 密度 | 1.256±0.06 g/cm3(Predicted) |
| 儲存條件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 酸水溶液（微溶） |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 2.58±0.20(Predicted) |
| 顏色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
| CAS 數(shù)據(jù)庫 | 20448-79-7(CAS DataBase Reference) |
| Target | Value |
|
LAT1
() |
LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.
LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase.
LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.
Cell Proliferation Assay
| Cell Line: | KYSE30 and KYSE150 esophageal cancer cells |
| Concentration: | 1 mM, 3 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, or 100 mM |
| Incubation Time: | 3 days |
| Result: | Cell proliferation was suppressed in a dose-dependent manner. |
Cell Cycle Analysis
| Cell Line: | KYSE30 and KYSE150 cells |
| Concentration: | 30 mM |
| Incubation Time: | 24 and 48 hours |
| Result: | Cell cycle arrest. |
Western Blot Analysis
| Cell Line: | KYSE30 and KYSE150 cells |
| Concentration: | 30 mM |
| Incubation Time: | 0 hour, 0.5 hour, 1 hour, 3 hours, 6 hours, 24 hours |
| Result: | Phosphorylation of 4E-BP1 and p70S6K was decreased. The amount of mTOR, 4E-BP1, and p70S6K proteins was slightly decreased. |
LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.
| Animal Model: | Male BALB/c nude mice (5-week-old) with KYSE150 cells |
| Dosage: | 200 mg/kg |
| Administration: | Intravenous injection; daily; for 14 days |
| Result: | Significantly delayed tumor growth and decreased glucose metabolism. |
安全信息
| WGK Germany | 3 |
|---|
| 提供商 | 語言 |
|---|---|
|
英文
|
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-108540 | 2-氨基-2-去甲菠烷羧酸 LAT1-IN-1 | 20448-79-7 | 50mg | 600元 |
| 2025/02/08 | HY-108540 | 2-氨基-2-去甲菠烷羧酸 LAT1-IN-1 | 20448-79-7 | 10mM * 1mLin Water | 660元 |