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4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid

4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:BMS 753
CAS:215307-86-1
Purity:98.4% Package:5mg;58USD|10mg;97USD|25mg;223USD
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:BMS 753
CAS:215307-86-1
Purity:>=98% Package:$117.9/5mg;$197.9/10mg;$444.9/25mg;$711.9/50mg;$1137.9/100mg;Bulk package Remarks:98%
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Products Intro: Product Name:BMS753
CAS:215307-86-1
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:BMS 753
CAS:215307-86-1
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:BMS 753
CAS:215307-86-1
Purity:98.00% Package:1mg;5mg;10mg

4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid manufacturers

  • BMS 753
  • BMS 753 pictures
  • $58.00 / 5mg
  • 2024-11-19
  • CAS:215307-86-1
  • Min. Order:
  • Purity: 98.4%
  • Supply Ability: 10g
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Basic information
Product Name:4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
Synonyms:Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-;4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate;4-(1,1,3,3-tetramethyl-2-oxo-2,3-dihydro-1H-indene-5-amido)benzoic acid;BMS 753, RARalpha agonist
CAS:215307-86-1
MF:C21H21NO4
MW:351.4
EINECS:
Product Categories:
Mol File:215307-86-1.mol
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Structure
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Chemical Properties
Boiling point 482.2±45.0 °C(Predicted)
density 1.240±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
pka4.26±0.10(Predicted)
form powder
color white to beige
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Usage And Synthesis
UsesBMS 753 is as been reported to be a RARα-selective agonist. Used to develop a series of small molecule inhibitors which affect specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease. This would aspire to reduce the attrition problem in drug discovery.
Biological ActivityBMS 753 is a subtype-selective retinoic acid receptor alpha (RARα) agonist with a Ki value of 2 nM for RARα.
in vitro

BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ -/- , but not activates in RARa -/- cells.

target

RARα

storageStore at RT
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Preparation Products And Raw materials
Tag:4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid(215307-86-1) Related Product Information