天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

113641-76-2

3-(4-iodophenyl)acrylic acid synthesis

4synthesis methods
-

Yield:113641-76-2 91%

Reaction Conditions:

with lithium hydroxide;water in tetrahydrofuran;methanol at 20; for 48 h;

Steps:



A solution of ethyl-4-iodo-cimiamate (3.2g, 10. 5mmol) in methanol (25mL), tetrahydrofuran (25mL) and water (15mL) was treated with lithium hydroxide monohydrate (4.2g, 100mmol) and the resulting reaction mixture was stirred at ambient temperature over 2 days. The volatiles were evaporated in vacuo and the residue was neutralized with saturated aqueous ammonium chloride solution. The precipitated solid was filtered, washed with water and hexane and dried to afford the title product as a white solid (2.9g, 91%) It was used as such for the next step.

References:

WO2005/58301,2005,A1 Location in patent:Page/Page column 76-77