| | 2062-78-4 Basic information More.. |
| Product Name: | Pimozide | | Synonyms: | PIMOZIDE;1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinon;1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone;1-(4,4-bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine;mcn-jr-6238;1-[1-(4,4-BIS[4-FLUOROPHENYL]BUTYL)-4-PIPERIDINYL]-1,3-DIHYDRO-2H-BENZ-IMIDAZOL-2-ONE;3-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidyl)-1H-benzimidazol-2-one;2H-Benzimidazol-2-one, 1-1-4,4-bis(4-fluorophenyl)butyl-4-piperidinyl-1,3-dihydro- | | CAS: | 2062-78-4 | | MF: | C28H29F2N3O | | MW: | 461.55 | | EINECS: | 218-171-7 | | Mol File: | 2062-78-4.mol |  |
Use
Pimozide, 1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone (Orap), isa white to creamy white solid (pKa＝9.42). Pimozide is 50%absorbed after oral administration. It is metabolized byCYP450 enzymes, in particular the CYP3A4 and CYP1A2isozymes, to inactive metabolites. Pimozide is excreted in theurine and to a lesser extent in the feces. Toxic effects may beproduced with pimozide in the presence of inducers or inhibitorsof CYP3A4 and CYP1A2. Pimozide is also a stronginhibitor of CYP2D6 without appearing to be an importantsubstrate of this isoform.99 The use of pimozide in the UnitedStates is small, but it is a critical drug for many patients withGilles de la Tourette disorder who cannot tolerate haloperidol.
- Pimozide
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- US $31.00-49.00 / mg
- 2024-11-19
- CAS:2062-78-4
- Min. Order:
- Purity: 99.83%
- Supply Ability: 10g
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2062-78-4
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