Budipin
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- CAS-Nr.
- 57982-78-2
- Bezeichnung:
- Budipin
- Englisch Name:
- BUDIPINE
- Synonyma:
- budipin;BUDIPINE;BUDIPINE USP/EP/BP;BUDIPINE(FORR&DONLY);4,4-diphenyl-1-tert-butyl-piperidine;1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE;1-(1,1-dimethylethyl)-4,4-diphenylpiperidine;1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin;Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl-;monoamine oxidase type B (MAO-B),inhibit,CNS disorders,Parkinson disease,Budipine,Inhibitor,dopaminergic
- CBNumber:
- CB2369325
- Summenformel:
- C21H27N
- Molgewicht:
- 293.45
- MOL-Datei:
- 57982-78-2.mol
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Budipin Eigenschaften
- Schmelzpunkt:
- 108.5°C
- Siedepunkt:
- 425.29°C (rough estimate)
- Dichte
- 0.9665 (rough estimate)
- Brechungsindex
- 1.4900 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO : 25 mg/mL (85.19 mM; Need ultrasonic)
- Aggregatzustand
- Solid
- pka
- 10.36±0.10(Predicted)
- Farbe
- Light yellow to khaki
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P310 |
Sofort GIFTINFORMATIONSZENTRUM/Arzt/ anrufen. |
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Budipin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Parkinsan was launched in Germany as a centrally-active anti-Parkinsonian
agent. It can be prepared in three steps: a Mannich-aldol sequence to assemble the
4-phenylpiperidine scaffold followed by a Friedel-Crafts reaction to introduce the
second phenyl ring. Parkinsan is effective for the treatment of Parkinsonian tremors
and is similar in action to, but more potent than, biperiden. It exhibits use-dependent,
open channel, uncompetitive NMDA receptor antagonistic activity. This may occur by
binding to the PCP site in addition to interacting with sigma, binding sites in the frontal
cortex. Parkinsan is also an antagonist at presynaptic muscarinic autoreceptors but
facilitation of direct or indirect dopaminergic transmission does not contribute to its
actions. While its mechanism of action is not completely understood, it has a weak
inhibitory effect on dopamine reuptake, inhibits evoked GABA release (with low affinity
for GABA-A receptors and a lower affinity for benzodiazepine receptors), and has a
weak inhibitory effect on MAO-B.
Budipin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Budipin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 58)Lieferanten
57982-78-2(Budipin)Verwandte Suche:
- BUDIPINE
- 1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin
- 1-(1,1-dimethylethyl)-4,4-diphenylpiperidine
- budipin
- 1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE
- BUDIPINE(FORR&DONLY)
- 4,4-diphenyl-1-tert-butyl-piperidine
- Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl-
- BUDIPINE USP/EP/BP
- monoamine oxidase type B (MAO-B),inhibit,CNS disorders,Parkinson disease,Budipine,Inhibitor,dopaminergic
- 57982-78-2
