ノナクチン
- ¥11900 - ¥310000
- 化學名: ノナクチン
- 英語名: NONACTIN
- 別名:ノナクチン;アンモニウムイオノフォアI;(3S)-3β,9β,12α,18α,21β,27β,30α,36α-オクタメチル-4β,7β:13α,16α:22β,25β:31α,34α-テトラエポキシ-1,10,19,28-テトラオキサシクロヘキサトリアコンタン-2,11,20,29-テトラオン;(3R)-3α,9α,12β,18β,21α,27α,30β,36β-オクタメチル-4α,7α:13β,16β:22α,25α:31β,34β-テトラエポキシ-1,10,19,28-テトラオキサシクロヘキサトリアコンタン-2,11,20,29-テトラオン;(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-オクタメチル-4,13,22,31,37,38,39,40-オクタオキサペンタシクロ[32.2.1.17,10.116,19.125,28]テトラコンタン-3,12,21,30-テトラオン
- CAS番號: 6833-84-7
- 分子式: C40H64O12
- 分子量: 736.93
- EINECS:229-911-3
- MDL Number:MFCD00043039
8物価
選択條件:
ブランド
- 富士フイルム和光純薬株式會社(wako)
- Sigma-Aldrich Japan
パッケージ
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01LKTN5652
- 製品説明ノナクチン
- 英語製品説明Nonactin
- 包裝単位1mg
- 価格¥11900
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01LKTN5652
- 製品説明ノナクチン
- 英語製品説明Nonactin
- 包裝単位5mg
- 価格¥23700
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01TOC2505
- 製品説明
- 英語製品説明Nonactin
- 包裝単位10mg
- 価格¥33000
- 更新しました2021-03-23
- 購入
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01LKTN5652
- 製品説明ノナクチン
- 英語製品説明Nonactin
- 包裝単位10mg
- 価格¥42700
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號N2286
- 製品説明ノナクチン from Streptomyces griseus, ≥98% (function tested, HPLC)
- 英語製品説明Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC)
- 包裝単位10mg
- 価格¥49300
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號09877
- 製品説明アンモニウムイオノフォアI Selectophore?, function tested, ≥95.0% (Nonactin, HPLC)
- 英語製品説明Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC)
- 包裝単位50mg
- 価格¥67800
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號N2286
- 製品説明ノナクチン from Streptomyces griseus, ≥98% (function tested, HPLC)
- 英語製品説明Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC)
- 包裝単位100mg
- 価格¥276000
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號09877
- 製品説明アンモニウムイオノフォアI Selectophore?, function tested, ≥95.0% (Nonactin, HPLC)
- 英語製品説明Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC)
- 包裝単位250mg
- 価格¥310000
- 更新しました2024-03-01
- 購入
生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式會社(wako) | W01LKTN5652 | ノナクチン Nonactin |
1mg | ¥11900 | 2024-03-01 | 購入 |
富士フイルム和光純薬株式會社(wako) | W01LKTN5652 | ノナクチン Nonactin |
5mg | ¥23700 | 2024-03-01 | 購入 |
富士フイルム和光純薬株式會社(wako) | W01TOC2505 | Nonactin |
10mg | ¥33000 | 2021-03-23 | 購入 |
富士フイルム和光純薬株式會社(wako) | W01LKTN5652 | ノナクチン Nonactin |
10mg | ¥42700 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | N2286 | ノナクチン from Streptomyces griseus, ≥98% (function tested, HPLC) Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC) |
10mg | ¥49300 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | 09877 | アンモニウムイオノフォアI Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) |
50mg | ¥67800 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | N2286 | ノナクチン from Streptomyces griseus, ≥98% (function tested, HPLC) Nonactin from Streptomyces griseus, ≥98% (function tested, HPLC) |
100mg | ¥276000 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | 09877 | アンモニウムイオノフォアI Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) Ammonium ionophore I Selectophore?, function tested, ≥95.0% (Nonactin, HPLC) |
250mg | ¥310000 | 2024-03-01 | 購入 |
プロパティ
融點 :147-148°
沸點 :890.6±65.0 °C(Predicted)
比重(密度) :1.11-1.15 g/cm3
貯蔵溫度 :2-8°C
溶解性 :chloroform: soluble10mg/mL
外見 :White to off-white crystalline solid.
色 :white to faint yellow
Sensitive :Moisture Sensitive
Merck :13,6709
BRN :76434
安定性: :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
沸點 :890.6±65.0 °C(Predicted)
比重(密度) :1.11-1.15 g/cm3
貯蔵溫度 :2-8°C
溶解性 :chloroform: soluble10mg/mL
外見 :White to off-white crystalline solid.
色 :white to faint yellow
Sensitive :Moisture Sensitive
Merck :13,6709
BRN :76434
安定性: :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
安全情報
絵表示(GHS): | |||||||||||||||||||||||||||||
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注意喚起語: | Warning | ||||||||||||||||||||||||||||
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注意書き: |
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説明
Nonactin is a cyclic ionophore and part of the macrotetrolide antibiotics family. The ionophore is commonly produced by several species of Streptomyces which selectively binds K+ and NH4+. Nonactin has been recorded to function by binding a metal ionophore and transporting it across cell membranes for release. The compound can functionally perform this transport due to its conformational flexibility and hydrophobic exterior. The compound forms a natural diastereomer which is required for its antibacterial and binding capacities.At a concentration of 1x10-7 M Nonactin uncoupled oxidative phosphorylation and induced ATP hydrolysis. The compound has been observed to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. In the presence of Thallus acetate, Nonactin has further stimulated the swelling of rat liver mitochondria than thallus acetate alone. It also has inhibited the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in MDR cancer cells. Nonactin has been shown to inhibit the production and gene transcription of IL-5 but not of IL-2 or IL-4. Nonactin has also been used as an ammonium ionophore for ammonium ion determination in a potentiometric electrode for biosensor construction as well as in a fluorescent immuno assay to detect K+ ions in pharmaceutical samples.
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