ML414(NGI-1)
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2物価
選択條件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番號SML1620
- 製品説明 ≥95% (HPLC)
- 英語製品説明NGI-1 ≥95% (HPLC)
- 包裝単位25mg
- 価格￥84400
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番號SML1620
- 製品説明 ≥95% (HPLC)
- 英語製品説明NGI-1 ≥95% (HPLC)
- 包裝単位5mg
- 価格￥21000
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML1620 | ≥95% (HPLC) NGI-1 ≥95% (HPLC) |
25mg | ￥84400 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | SML1620 | ≥95% (HPLC) NGI-1 ≥95% (HPLC) |
5mg | ￥21000 | 2024-03-01 | 購入 |
プロパティ
比重(密度) :1.372±0.06 g/cm3(Predicted)
貯蔵溫度 :2-8°C
溶解性 :Soluble in DMSO (up to 5 mg/ml)
酸解離定數(shù)(Pka) :7.48±0.50(Predicted)
外見 :powder
色 :white to beige
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
貯蔵溫度 :2-8°C
溶解性 :Soluble in DMSO (up to 5 mg/ml)
酸解離定數(shù)(Pka) :7.48±0.50(Predicted)
外見 :powder
色 :white to beige
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
安全情報
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説明
NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.関連製品価格
ML213 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone 1-(3,4-ジフルオロフェニル)-3-(1-フェニル-3-メチル-1H-ピラゾール-5-イル)尿素 ML277 ML 18 ML-228 ML221 ML216 ML161 1-[(5-クロロ-1-ナフタレニル)スルホニル]ヘキサヒドロ-1H-1,4-ジアゼピン·塩酸塩 4-Methyl-2-(1-piperidinyl)-quinoline M348 1-(4-(4-(benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethan-1-one ML234 ML193 ML281 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] ML365 CID-49830258 ML385関連商品価格
- ML213
￥16000-1068100 - [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
￥25600-95700 - 1-(3,4-ジフルオロフェニル)-3-(1-フェニル-3-メチル-1H-ピラゾール-5-イル)尿素
￥17000-235000