リナクロチド
- ¥48800 - ¥385000
- 化學(xué)名: リナクロチド
- 英語(yǔ)名: Linaclotide
- 別名:リナクロチド;リナクロチド (JAN);(2S)-2-{[(1R,4S,7S,13S,16R,21R,24R,27S,30S,33R,38R,44S)-21-アミノ-13-(カルバモイルメチル)-27-(2-カルボキシエチル)-44-[(1R)-1-ヒドロキシエチル]-30-[(4-ヒドロキシフェニル)メチル]-4-メチル-3,6,12,15,22,25,28,31,40,43,46,51-ドデカオキソ-18,19,35,36,48,49-ヘキサチア-2,5,11,14,23,26,29,32,39,42,45,52-ドデカアザテトラシクロ[22.22.4.216,33.07,11]ドペンタコンタン-38-イル]ホルムアミド}-3-(4-ヒドロキシフェニル)プロパン酸;リンゼス
- CAS番號(hào): 851199-59-2
- 分子式: C59H79N15O21S6
- 分子量: 1526.74
- EINECS:251-228-4
- MDL Number:MFCD20526656
2物価
選択條件:
ブランド
- 富士フイルム和光純薬株式會(huì)社(wako)
パッケージ
- 10mg
- 100mg
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01TRCL465880
- 製品説明リナクロチド
- 英語(yǔ)製品説明Linaclotide
- 包裝単位100mg
- 価格¥385000
- 更新しました2021-03-23
- 購(gòu)入
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01TRCL465880
- 製品説明リナクロチド
- 英語(yǔ)製品説明Linaclotide
- 包裝単位10mg
- 価格¥48800
- 更新しました2021-03-23
- 購(gòu)入
生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購(gòu)入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式會(huì)社(wako) | W01TRCL465880 | リナクロチド Linaclotide |
100mg | ¥385000 | 2021-03-23 | 購(gòu)入 |
富士フイルム和光純薬株式會(huì)社(wako) | W01TRCL465880 | リナクロチド Linaclotide |
10mg | ¥48800 | 2021-03-23 | 購(gòu)入 |
プロパティ
融點(diǎn) :231-235°C (dec.)
沸點(diǎn) :2045.0±65.0 °C(Predicted)
比重(密度) :1.60
貯蔵溫度 :Hygroscopic, Refrigerator, under inert atmosphere
溶解性 :DMSO (Slightly, Heated), Methanol ((Slightly, Heated)), Water (Slightly, Heated)
酸解離定數(shù)(Pka) :3.05±0.10(Predicted)
外見 :Solid
色 :White
安定性: :Hygroscopic
InChIKey :KXGCNMMJRFDFNR-VRMHCMCOSA-N
沸點(diǎn) :2045.0±65.0 °C(Predicted)
比重(密度) :1.60
貯蔵溫度 :Hygroscopic, Refrigerator, under inert atmosphere
溶解性 :DMSO (Slightly, Heated), Methanol ((Slightly, Heated)), Water (Slightly, Heated)
酸解離定數(shù)(Pka) :3.05±0.10(Predicted)
外見 :Solid
色 :White
安定性: :Hygroscopic
InChIKey :KXGCNMMJRFDFNR-VRMHCMCOSA-N
安全情報(bào)
絵表示(GHS): | |||||||||||||||
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注意喚起語(yǔ): | Warning | ||||||||||||||
危険有害性情報(bào): |
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注意書き: |
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説明
In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.関連商品価格
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