BI 6015
|
2物価
選択條件：
ブランド
- 富士フイルム和光純薬株式會(huì)社(wako)
パッケージ
- 10mg
- 50mg
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01TOC4641
- 製品説明
- 英語製品説明BI 6015
- 包裝単位10mg
- 価格￥71000
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01TOC4641
- 製品説明
- 英語製品説明BI 6015
- 包裝単位50mg
- 価格￥291000
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式會(huì)社(wako) | W01TOC4641 | BI 6015 |
10mg | ￥71000 | 2024-03-01 | 購入 |
| 富士フイルム和光純薬株式會(huì)社(wako) | W01TOC4641 | BI 6015 |
50mg | ￥291000 | 2024-03-01 | 購入 |
プロパティ
沸點(diǎn) :570.6±60.0 °C(Predicted)
比重(密度) :1.45±0.1 g/cm3(Predicted)
貯蔵溫度 :+2C to +8C
溶解性 :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
外見 :Beige powder
酸解離定數(shù)(Pka) :0.88±0.10(Predicted)
色 :Tan
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
比重(密度) :1.45±0.1 g/cm3(Predicted)
貯蔵溫度 :+2C to +8C
溶解性 :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
外見 :Beige powder
酸解離定數(shù)(Pka) :0.88±0.10(Predicted)
色 :Tan
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
安全情報(bào)
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説明
Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BI6015 is a small molecule antagonist of Hepatocyte nuclear factor 4α (HNF4α) that has been shown to repress the expression of known HNF4α target genes. At concentrations up to 20 μM, BI6015 has been shown to reduce endogenous insulin gene expression by as much as 50-fold in T6PNE cells. The hepatocytes from livers of mice injected with 10 and 30 mg/kg BI6015 exhibit marked, dose-dependent fat accumulation (steatosis). Additionally, at a daily dose of 30 mg/kg, BI6015 induces apoptosis in a human hepatocellular carcinoma mouse model.関連商品価格
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