R788(Fostamatinib disodium)
2物価
選択條件:
ブランド
- 富士フイルム和光純薬株式會社(wako)
パッケージ
- 1mg
- 5mg
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01BVI1936-5
- 製品説明
- 英語製品説明Fostamatinib Disodium
- 包裝単位5mg
- 価格¥102700
- 更新しました2020-09-21
- 購入
- 生産者富士フイルム和光純薬株式會社(wako)
- 製品番號W01BVI1936-1
- 製品説明
- 英語製品説明Fostamatinib Disodium
- 包裝単位1mg
- 価格¥26000
- 更新しました2020-09-21
- 購入
生産者 | 製品番號 | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式會社(wako) | W01BVI1936-5 | Fostamatinib Disodium |
5mg | ¥102700 | 2020-09-21 | 購入 |
富士フイルム和光純薬株式會社(wako) | W01BVI1936-1 | Fostamatinib Disodium |
1mg | ¥26000 | 2020-09-21 | 購入 |
プロパティ
融點(diǎn) :>191°C (dec.)
貯蔵溫度 :Store at -20°C
溶解性 :DMSO (Slightly), Methanol (Slightly)
外見 :Solid
色 :Off-White
安定性: :Hygroscopic
貯蔵溫度 :Store at -20°C
溶解性 :DMSO (Slightly), Methanol (Slightly)
外見 :Solid
色 :Off-White
安定性: :Hygroscopic
安全情報(bào)
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説明
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. R788 is a prodrug of R406 , an inhibitor of Syk (Ki = 30 nM). R788 conversion to the biologically active R406 is catalyzed by the action of alkaline phosphatases present on the apical brush-border of the membranes of intestinal enterocytes. It produces anti-inflammatory and immunomodulating effects by inhibiting Syk-mediated IgG Fcγ receptor signaling, which prevents activation of mast cells, macrophages, and B cells, as well as related inflammatory responses. R788 has undergone clinical evaluation for efficacy in the treatment of rheumatoid arthritis.関連商品価格
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