UNC-0642
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- $36 - $1946
- Product name: UNC-0642
- CAS: 1481677-78-4
- MF: C29H44F2N6O2
- MW: 546.7
- EINECS:
- MDL Number:MFCD28044322
- Synonyms:UNC 0642;UNC0642;UNC-0642;2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine;UNC0642, 2-(4,4-Difluoro-1-piperidinyl)-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;UNC-0642;UNC0642;UNC 0642
30 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 1mg
- 10mg
- 25mg
- 10mM(in 1mL DMSO)
- 5mg
- 50
- 10
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5374
- Product descriptionUNC0642
- Packaging50mg
- Price$617
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging1g
- Price$1946
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging250mg
- Price$865
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging100mg
- Price$517
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging50mg
- Price$355
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging25mg
- Price$272
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging10mg
- Price$137
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging5mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464128
- Product description2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+%
- Packaging1mg
- Price$36
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7757
- Product descriptionUNC0642
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7757
- Product descriptionUNC0642
- Packaging10mM(in 1mL DMSO)
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7757
- Product descriptionUNC0642
- Packaging50mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14604
- Product descriptionUNC0642 ≥95%
- Packaging1mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14604
- Product descriptionUNC0642 ≥95%
- Packaging5mg
- Price$180
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14604
- Product descriptionUNC0642 ≥95%
- Packaging10mg
- Price$270
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM142730
- Product description2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98%
- Packaging100mg
- Price$763
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5374 | UNC0642 | 50mg | $617 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 1g | $1946 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 250mg | $865 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 100mg | $517 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 50mg | $355 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 25mg | $272 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 10mg | $137 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 5mg | $69 | 2021-12-16 | Buy |
| Ambeed | A464128 | 2-(4,4-Difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98+% | 1mg | $36 | 2021-12-16 | Buy |
| ApexBio Technology | B7757 | UNC0642 | 10mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | B7757 | UNC0642 | 10mM(in 1mL DMSO) | $120 | 2021-12-16 | Buy |
| ApexBio Technology | B7757 | UNC0642 | 50mg | $380 | 2021-12-16 | Buy |
| Cayman Chemical | 14604 | UNC0642 ≥95% | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14604 | UNC0642 ≥95% | 5mg | $180 | 2024-03-01 | Buy |
| Cayman Chemical | 14604 | UNC0642 ≥95% | 10mg | $270 | 2024-03-01 | Buy |
| Chemenu | CM142730 | 2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 98% | 100mg | $763 | 2021-12-16 | Buy |
Properties
Boiling point :679.2±65.0 °C(Predicted)
Density :1.23±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
pka :10.06±0.20(Predicted)
form :powder
color :white to beige
Density :1.23±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
pka :10.06±0.20(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferases G9a and G9a-like protein (GLP) can mono- or dimethylate lysine 9 on histone 3, contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0642 is a selective inhibitor of G9a and GLP that competitively inhibits binding of H3K9 substrates with a Ki = 3.7 nM. It exhibits >2,000-fold selectivity over the lysine methyltransferase EZH2 and >20,000-fold selectivity over other methyltransferases. UNC0642 has been shown to reduce H3K9 dimethylation levels in MDA-MB-231 and PANC-1 cells with IC50 values of 110 and 40 nM, respectively. Furthermore, it displays improved pharmacokinetic properties relative to UNC0638 . See the Structural Genomics Consortium (SGC) website for more information.Related product price
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