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ChemicalBook >> CAS DataBase List >> Temsirolimus

Temsirolimus

Temsirolimus price.
  • $46 - $1444
  • Product name: Temsirolimus
  • CAS: 162635-04-3
  • MF: C56H87NO16
  • MW: 1030.29
  • EINECS:686-177-0
  • MDL Number:MFCD00934421
  • Synonyms:42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropa;Temsirolimus(CCI-779);TEMSIROLIMUS;CCL-779;Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate;TeMsiroliMus (CCI-779, Torisel);rapaMycin 42-ester with 3-hydroxy-2-(hydroxyMethyl)-2-Methylpropionic acid;42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin
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  • AK Scientific
  • Alfa Aesar
  • Ambeed
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  • Arctom
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  • Biosynth Carbosynth
  • Cayman Chemical
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  • Matrix Scientific
  • Medical Isotopes, Inc.
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  • Usbiological
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  • 100mg
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  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberB622
  • Product descriptionTemsirolimus
  • Packaging1mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberB622
  • Product descriptionTemsirolimus
  • Packaging25mg
  • Price$257
  • Updated2021-12-16
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  • ManufacturerAlfa Aesar
  • Product numberJ63654
  • Product descriptionTemsirolimus 99+%
  • Packaging25mg
  • Price$318
  • Updated2023-06-20
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ63654
  • Product descriptionTemsirolimus 99+%
  • Packaging50mg
  • Price$585
  • Updated2023-06-20
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  • ManufacturerAlfa Aesar
  • Product numberJ63654
  • Product descriptionTemsirolimus 99+%
  • Packaging100mg
  • Price$776
  • Updated2023-06-20
  • Buy
  • ManufacturerAmbeed
  • Product numberA642622
  • Product descriptionTemsirolimus 99%
  • Packaging5mg
  • Price$46
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA642622
  • Product descriptionTemsirolimus 99%
  • Packaging10mg
  • Price$69
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA642622
  • Product descriptionTemsirolimus 99%
  • Packaging25mg
  • Price$146
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA642622
  • Product descriptionTemsirolimus 99%
  • Packaging100mg
  • Price$382
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA642622
  • Product descriptionTemsirolimus 99%
  • Packaging250mg
  • Price$597
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA642622
  • Product descriptionTemsirolimus 99%
  • Packaging1g
  • Price$1444
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8314
  • Product descriptionTemsirolimus
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN60122
  • Product descriptionTemsirolimus(CCI-779)
  • Packaging20mg
  • Price$288
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3349
  • Product descriptionTemsirolimus
  • Packaging5mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3349
  • Product descriptionTemsirolimus
  • Packaging10mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3349
  • Product descriptionTemsirolimus
  • Packaging100mg
  • Price$279
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific B622 Temsirolimus 1mg $49 2021-12-16 Buy
AK Scientific B622 Temsirolimus 25mg $257 2021-12-16 Buy
Alfa Aesar J63654 Temsirolimus 99+% 25mg $318 2023-06-20 Buy
Alfa Aesar J63654 Temsirolimus 99+% 50mg $585 2023-06-20 Buy
Alfa Aesar J63654 Temsirolimus 99+% 100mg $776 2023-06-20 Buy
Ambeed A642622 Temsirolimus 99% 5mg $46 2021-12-16 Buy
Ambeed A642622 Temsirolimus 99% 10mg $69 2021-12-16 Buy
Ambeed A642622 Temsirolimus 99% 25mg $146 2021-12-16 Buy
Ambeed A642622 Temsirolimus 99% 100mg $382 2021-12-16 Buy
Ambeed A642622 Temsirolimus 99% 250mg $597 2021-12-16 Buy
Ambeed A642622 Temsirolimus 99% 1g $1444 2021-12-16 Buy
ApexBio Technology A8314 Temsirolimus 10mg $85 2021-12-16 Buy
Arctom CFN60122 Temsirolimus(CCI-779) 20mg $288 2021-12-16 Buy
AvaChem 3349 Temsirolimus 5mg $49 2021-12-16 Buy
AvaChem 3349 Temsirolimus 10mg $59 2021-12-16 Buy
AvaChem 3349 Temsirolimus 100mg $279 2021-12-16 Buy

Properties

Melting point :99-101°C
Boiling point :1048.4±75.0 °C(Predicted)
Density :1.21
Flash point :587.8℃
storage temp. :room temp
solubility :Soluble in chloroform, methanol.
pka :10.40±0.70(Predicted)
form :powder
color :white to off-white
Merck :14,9142
InChIKey :CBPNZQVSJQDFBE-FUXHJELOSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Rapamycin is an immunosuppressant that specifically interacts with the cytosolic FK-binding protein 12 to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1. Temsirolimus is a dihydroxymethyl propionic acid ester of rapamycin with improved solubility that specifically inhibits mTOR signaling with a potency similar to that of rapamycin. Treatment with temsirolimus leads to cell cycle arrest in the G1 phase and also inhibition of tumor angiogenesis by reducing synthesis of VEGF. Temsirolimus demonstrates cytostatic activity in several xenograft models of human tumors in nude mice, including glioblastomas, prostate carcinoma, pancreatic, liver, and breast cancers, and medulloblastoma.

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