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ChemicalBook >> CAS DataBase List >> THIOSTREPTON

THIOSTREPTON

THIOSTREPTON price.
  • $6 - $1216.45
  • Product name: THIOSTREPTON
  • CAS: 1393-48-2
  • MF: C72H85N19O18S5
  • MW: 1664.89
  • EINECS:215-734-9
  • MDL Number:MFCD00135828
  • Synonyms:Thiostrepton (200 mg);BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31;Thiostrepton, froM StreptoMyces sp.;x146 ;THIOSTREPTON;Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy;THIOSTREPTION;thiostrepton from streptomyces azureus
27 prices
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Brand
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 10mg
  • 5mg
  • 50
  • 50mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAlfa Aesar
  • Product numberJ62332
  • Product descriptionThiostrepton, Streptomyces laurentii, 90+%
  • Packaging1g
  • Price$201
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62332
  • Product descriptionThiostrepton, Streptomyces laurentii, 90+%
  • Packaging5g
  • Price$705
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265605
  • Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
  • Packaging1mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265605
  • Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
  • Packaging10mg
  • Price$14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265605
  • Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
  • Packaging50mg
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265605
  • Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
  • Packaging250mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004400
  • Product descriptionThiostrepton 95.00%
  • Packaging1G
  • Price$693.92
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004400
  • Product descriptionThiostrepton 95.00%
  • Packaging5G
  • Price$1216.45
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7336
  • Product descriptionThiostrepton
  • Packaging50mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIT1003
  • Product descriptionThiostrepton from Streptomyces azureus
  • Packaging250mg
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIT1003
  • Product descriptionThiostrepton from Streptomyces azureus
  • Packaging1g
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIT1003
  • Product descriptionThiostrepton from Streptomyces azureus
  • Packaging5g
  • Price$653
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545980
  • Product descriptionThiostrepton >98%
  • Packaging1g
  • Price$217.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545980
  • Product descriptionThiostrepton >98%
  • Packaging5G
  • Price$620.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19200
  • Product descriptionThiostrepton ≥95%
  • Packaging500mg
  • Price$65
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19200
  • Product descriptionThiostrepton ≥95%
  • Packaging1g
  • Price$96
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar J62332 Thiostrepton, Streptomyces laurentii, 90+% 1g $201 2024-03-01 Buy
Alfa Aesar J62332 Thiostrepton, Streptomyces laurentii, 90+% 5g $705 2021-12-16 Buy
Ambeed A265605 N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% 1mg $6 2021-12-16 Buy
Ambeed A265605 N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% 10mg $14 2021-12-16 Buy
Ambeed A265605 N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% 50mg $32 2021-12-16 Buy
Ambeed A265605 N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% 250mg $70 2021-12-16 Buy
American Custom Chemicals Corporation API0004400 Thiostrepton 95.00% 1G $693.92 2021-12-16 Buy
American Custom Chemicals Corporation API0004400 Thiostrepton 95.00% 5G $1216.45 2021-12-16 Buy
ApexBio Technology B7336 Thiostrepton 50mg $50 2021-12-16 Buy
Apolloscientific BIT1003 Thiostrepton from Streptomyces azureus 250mg $73 2021-12-16 Buy
Apolloscientific BIT1003 Thiostrepton from Streptomyces azureus 1g $170 2021-12-16 Buy
Apolloscientific BIT1003 Thiostrepton from Streptomyces azureus 5g $653 2021-12-16 Buy
Biorbyt Ltd orb545980 Thiostrepton >98% 1g $217.6 2021-12-16 Buy
Biorbyt Ltd orb545980 Thiostrepton >98% 5G $620.5 2021-12-16 Buy
Cayman Chemical 19200 Thiostrepton ≥95% 500mg $65 2024-03-01 Buy
Cayman Chemical 19200 Thiostrepton ≥95% 1g $96 2024-03-01 Buy

Properties

Melting point :248-257°C (dec.)
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.

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