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ChemicalBook >> CAS DataBase List >> Ripasudil

Ripasudil

Ripasudil price.
  • $154 - $1290
  • Product name: Ripasudil
  • CAS: 223645-67-8
  • MF: C15H18FN3O2S
  • MW: 323.39
  • EINECS:-0
  • MDL Number:MFCD28291829
  • Synonyms:k115 free base;Ripasudil;4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline;RIPASUDIL FREE BASE;K 115 FREE BASE;K115 FREE BASE;CS-1564;K-115, Ripasudil;Isoquinoline, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-;RIPASUDIL HYDROCHLOIDE
5 prices
Selected condition：
Brand
  • Chemenu
  • Crysdot
  • CSNpharm
Package
  • 5mg
  • 25mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerChemenu
  • Product numberCM146182
  • Product description(S)-4-fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline 98%
  • Packaging100mg
  • Price$880
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002611
  • Product descriptionK-115freebase 98+%
  • Packaging250mg
  • Price$515
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002611
  • Product descriptionK-115freebase 98+%
  • Packaging1g
  • Price$1290
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16953
  • Product descriptionK-115
  • Packaging5mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16953
  • Product descriptionK-115
  • Packaging25mg
  • Price$557
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Chemenu CM146182 (S)-4-fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline 98% 100mg $880 2021-12-16 Buy
Crysdot CD31002611 K-115freebase 98+% 250mg $515 2021-12-16 Buy
Crysdot CD31002611 K-115freebase 98+% 1g $1290 2021-12-16 Buy
CSNpharm CSN16953 K-115 5mg $154 2021-12-16 Buy
CSNpharm CSN16953 K-115 25mg $557 2021-12-16 Buy

Properties

Boiling point :497.2±55.0 °C(Predicted)
Density :1.293±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO
pka :9.70±0.40(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ripasudil (Glanatec TM, Kowa Pharmaceutical), a close derivative of fasudil, is another Rho kinase inhibitor approved in Japan at the end of 2014 for the treatment of glaucoma and ocular hypertensionwhen other therapeutic agents are not effective or cannot be administered. Additionally, ripasudil has been tested in diabetic retinopathy clinical trials and shown to promote corneal endothelial cell proliferation, endothelium regeneration, and wound healing.

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