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ChemicalBook >> CAS DataBase List >> PIERICIDIN A

PIERICIDIN A

PIERICIDIN A price.
  • $135 - $1050
  • Product name: PIERICIDIN A
  • CAS: 2738-64-9
  • MF: C25H37NO4
  • MW: 415.57
  • EINECS:
  • MDL Number:MFCD16661265
  • Synonyms:,5,7,11-tetramethyl-,(all-e)-(4s,5s)- ;2,6,9,11-tridecatetraen-4-ol,13-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridyl)-3 ;piericidin ;piericidin(sub1) ;piericidinea ;SN 198E;SHAOGUAMYCIN B;SHAOGUANMYCIN B
8 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • TRC
  • Usbiological
Package
  • 200ug
  • 1mg
  • 2.5mg
  • 5mg
  • ManufacturerAK Scientific
  • Product number3261BB
  • Product descriptionPiericidinA
  • Packaging5mg
  • Price$775
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3535
  • Product descriptionPiericidinA
  • Packaging1mg
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546184
  • Product descriptionPiericidin A >98%
  • Packaging200ug
  • Price$136
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb546184
  • Product descriptionPiericidin A >98%
  • Packaging1mg
  • Price$307.7
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15379
  • Product descriptionPiericidin A ≥95%
  • Packaging1mg
  • Price$135
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15379
  • Product descriptionPiericidin A ≥95%
  • Packaging5mg
  • Price$641
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberP991778
  • Product descriptionPiericidinA
  • Packaging2.5mg
  • Price$1050
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product numberP4155
  • Product descriptionPiericidin A
  • Packaging1mg
  • Price$408
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3261BB PiericidinA 5mg $775 2021-12-16 Buy
ApexBio Technology C3535 PiericidinA 1mg $173 2021-12-16 Buy
Biorbyt Ltd orb546184 Piericidin A >98% 200ug $136 2021-12-16 Buy
Biorbyt Ltd orb546184 Piericidin A >98% 1mg $307.7 2021-12-16 Buy
Cayman Chemical 15379 Piericidin A ≥95% 1mg $135 2024-03-01 Buy
Cayman Chemical 15379 Piericidin A ≥95% 5mg $641 2024-03-01 Buy
TRC P991778 PiericidinA 2.5mg $1050 2021-12-16 Buy
Usbiological P4155 Piericidin A 1mg $408 2021-12-16 Buy

Properties

Boiling point :614.9±55.0 °C(Predicted)
Density :1.044±0.06 g/cm3(Predicted)
Flash point :85 °C
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
pka :5.21±0.33(Predicted)
form :liquid
color :green-yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Complex I, also known as NADH:ubiquinone oxidoreductase or NADH dehydrogenase (ubiquinone), catalyzes the transfer of electrons from NADH to ubiquinone (also known as coenzyme Q10) as part of the respiratory chain leading to ATP generation. Piericidin A is an irreversible inhibitor of mitochondrial complex I that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme. First identified as an insecticidal metabolite produced by Streptomyces, piericidin A was soon found to bind and inhibit complex I at nanomolar concentrations. The inhibition of complex I by piericidin A in the presence of NADH results in the generation of reactive oxygen species. In plants, pieridicin A inhibits photosystem II, a water-plastoquinone oxidoreductase involved in light-dependent electron transfer. Piericidin A also suppresses the up-regulation of the glucose-regulated protein GRP78 in glucose-deprived, etoposide-resistant HT-29 cells, resulting in cell death (IC50 = 7.7 nM).

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