PF-05089771 (tosylate)
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- $98 - $532
- Product name: PF-05089771 (tosylate)
- CAS: 1430806-04-4
- MF: C25H20Cl2FN5O6S3
- MW: 672.5556032
- EINECS:
- MDL Number:MFCD30146405
- Synonyms:PF-05089771 (tosylate);4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate;PF-05089771 >=98% (HPLC);PF 05089771 tosylate,TTX-R,pain,Na channels,PF-05089771,neuropathy,diabetic,Sodium Channel,PF05089771,inhibit,PF 05089771,tetrodotoxin,Na+ channels,Inhibitor;PF0508977;4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide, monomethylbenzenesulfonate
8 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 5mg
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number9314DU
- Product descriptionPF-05089771tosylate
- Packaging5mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9314DU
- Product descriptionPF-05089771tosylate
- Packaging25mg
- Price$532
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number24449
- Product descriptionPF-05089771 (tosylate) ≥98%
- Packaging5mg
- Price$98
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24449
- Product descriptionPF-05089771 (tosylate) ≥98%
- Packaging10mg
- Price$186
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24449
- Product descriptionPF-05089771 (tosylate) ≥98%
- Packaging25mg
- Price$389
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberPZ0311
- Product descriptionPF-05089771 ≥98% (HPLC)
- Packaging5MG
- Price$105
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberPZ0311
- Product descriptionPF-05089771 ≥98% (HPLC)
- Packaging25MG
- Price$424
- Updated2023-06-20
- Buy
- ManufacturerTRC
- Product numberP294125
- Product descriptionPF05089771
- Packaging10mg
- Price$415
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9314DU | PF-05089771tosylate | 5mg | $208 | 2021-12-16 | Buy |
| AK Scientific | 9314DU | PF-05089771tosylate | 25mg | $532 | 2021-12-16 | Buy |
| Cayman Chemical | 24449 | PF-05089771 (tosylate) ≥98% | 5mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 24449 | PF-05089771 (tosylate) ≥98% | 10mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 24449 | PF-05089771 (tosylate) ≥98% | 25mg | $389 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0311 | PF-05089771 ≥98% (HPLC) | 5MG | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | PZ0311 | PF-05089771 ≥98% (HPLC) | 25MG | $424 | 2023-06-20 | Buy |
| TRC | P294125 | PF05089771 | 10mg | $415 | 2021-12-16 | Buy |
Properties
storage temp. :room temp
solubility :DMF: 33 mg/ml; DMSO: 33 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form :powder
color :white to beige
solubility :DMF: 33 mg/ml; DMSO: 33 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form :powder
color :white to beige
Safety Information
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Description
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50s = ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50s = 10 and 20 μM, respectively). PF-05089771 is also 1,000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation of the domain IV voltage-sensor domain (VSD4) reduces PF-05089771 potency by approximately 100-fold.More related product prices
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