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ChemicalBook >> CAS DataBase List >> Naloxone

Naloxone

Naloxone price.
  • $38.1 - $945.95
  • Product name: Naloxone
  • CAS: 465-65-6
  • MF: C19H21NO4
  • MW: 327.37
  • EINECS:207-365-7
  • MDL Number:MFCD00242634
  • Synonyms:12-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4ah-8,9c-iminoethanophenanthro(4,5 ;12-allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4ah-8,9c-iminoethanophenanthro[4,5 ;17-allyl-4,5alpha-epoxy-3,14-dihydroxy-morphinan-6-on ;17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one ;17-allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one ;1-n-allyl-14-hydroxynordihydromorphinone ;1-n-allyl-7,8-dihydro-14-hydroxynormorphinone ;4,5-alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-on
5 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Chemtos
  • Sigma-Aldrich
  • TRC
Package
  • 0.1mg
  • 5mg
  • 200mg
  • 1G
  • 1mL
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003490
  • Product descriptionN-ALLYLNOROXYMORPHONE 95.00%
  • Packaging1G
  • Price$945.95
  • Updated2021-12-16
  • Buy
  • ManufacturerChemtos
  • Product numberSL-N-00630
  • Product descriptionNaloxone-d50.1mg/ml
  • Packaging0.1mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number1453005
  • Product descriptionNaloxone United States Pharmacopeia (USP) Reference Standard
  • Packaging200mg
  • Price$358
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberN-004
  • Product descriptionNaloxone solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1mL
  • Price$38.1
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberN284995
  • Product descriptionNaloxone
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0003490 N-ALLYLNOROXYMORPHONE 95.00% 1G $945.95 2021-12-16 Buy
Chemtos SL-N-00630 Naloxone-d50.1mg/ml 0.1mg $250 2021-12-16 Buy
Sigma-Aldrich 1453005 Naloxone United States Pharmacopeia (USP) Reference Standard 200mg $358 2024-03-01 Buy
Sigma-Aldrich N-004 Naloxone solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1mL $38.1 2024-03-01 Buy
TRC N284995 Naloxone 5mg $90 2021-12-16 Buy

Properties

Melting point :184° (Lewenstein), 177-178° (Sankyo Co.)
alpha :D20 -194.5° (c = 0.93 in CHCl3)
Boiling point :465.27°C (rough estimate)
Density :1.2223 (rough estimate)
refractive index :1.5000 (estimate)
Flash point :9℃
storage temp. :2-8°C
solubility :Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly),
form :Solid
pka :pKa 7.94/7.82(H2O,t =20/37,I<0.01) (Uncertain)
color :White to Off-White
InChIKey :UZHSEJADLWPNLE-GRGSLBFTSA-N
EPA Substance Registry System :Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5.alpha.)- (465-65-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501 Dispose of contents/container to..…

Description

It is worth mentioning that N-allylic substitution in a number of morphine derivatives, as a rule, leads to antagonistic properties. Naloxone is a few times stronger than nalorphine as an antagonist. It blocks opiate receptors. It eliminates central and peripheral action of opioids, including respiratory depression. Naloxone is used upon overdose of narcotic analgesics.

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