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ChemicalBook >> CAS DataBase List >> ML277

ML277

ML277 price.
  • $44 - $2100
  • Product name: ML277
  • CAS: 1401242-74-7
  • MF: C23H25N3O4S2
  • MW: 471.59
  • EINECS:
  • MDL Number:MFCD28133374
  • Synonyms:VU0458298-2, VU0458298-3;ML277;(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;CID-53347902;ML277;ML 277; ML-277;(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide;(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
25 prices
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Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1mg
  • 10
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5303
  • Product descriptionML277
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA576326
  • Product description(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA576326
  • Product description(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+%
  • Packaging10mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA576326
  • Product description(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+%
  • Packaging25mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA576326
  • Product description(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+%
  • Packaging50mg
  • Price$191
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA576326
  • Product description(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+%
  • Packaging100mg
  • Price$281
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA576326
  • Product description(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+%
  • Packaging250mg
  • Price$397
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA576326
  • Product description(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+%
  • Packaging1g
  • Price$991
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7711
  • Product descriptionML277
  • Packaging10mg
  • Price$224
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15193
  • Product descriptionML-277 ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15193
  • Product descriptionML-277 ≥95%
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15193
  • Product descriptionML-277 ≥95%
  • Packaging10mg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15193
  • Product descriptionML-277 ≥95%
  • Packaging25mg
  • Price$267
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3353
  • Product descriptionML277 99.43%
  • Packaging5mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3353
  • Product descriptionML277 99.43%
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3353
  • Product descriptionML277 99.43%
  • Packaging50mg
  • Price$696
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5303 ML277 10mg $160 2021-12-16 Buy
Ambeed A576326 (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+% 5mg $60 2021-12-16 Buy
Ambeed A576326 (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+% 10mg $109 2021-12-16 Buy
Ambeed A576326 (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+% 25mg $147 2021-12-16 Buy
Ambeed A576326 (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+% 50mg $191 2021-12-16 Buy
Ambeed A576326 (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+% 100mg $281 2021-12-16 Buy
Ambeed A576326 (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+% 250mg $397 2021-12-16 Buy
Ambeed A576326 (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide 98+% 1g $991 2021-12-16 Buy
ApexBio Technology B7711 ML277 10mg $224 2021-12-16 Buy
Cayman Chemical 15193 ML-277 ≥95% 1mg $44 2024-03-01 Buy
Cayman Chemical 15193 ML-277 ≥95% 5mg $118 2024-03-01 Buy
Cayman Chemical 15193 ML-277 ≥95% 10mg $172 2024-03-01 Buy
Cayman Chemical 15193 ML-277 ≥95% 25mg $267 2024-03-01 Buy
ChemScene CS-3353 ML277 99.43% 5mg $94 2021-12-16 Buy
ChemScene CS-3353 ML277 99.43% 10mg $170 2021-12-16 Buy
ChemScene CS-3353 ML277 99.43% 50mg $696 2021-12-16 Buy

Properties

Density :1.341±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 5 mg/ml
pka :8.37±0.70(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.

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