JAK INHIBITOR I
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- $29 - $5366
- Product name: JAK INHIBITOR I
- CAS: 457081-03-7
- MF: C18H16FN3O
- MW: 309.34
- EINECS:
- MDL Number:MFCD17019334
- Synonyms:Merck-5;MERk-5;2-(tert-butyl)-9-fluoro-3H-benzo[h]iMidazo[4,5-f]isoquinolin-7(6H)-one;CMP 6;2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one;Pyridone 6, >=98%;2-(1,1-DIMETHYLETHYL)-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F] ISOQUINOLIN-7-ONE;JAK INHIBITOR I
38 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 1mg
- 2mg
- 50mg
- 50
- 500μg
- 5mg
- 10mg
- 100mg
- 200mg
- 250mg
- 10mM(in 1mL DMSO)
- 1000mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1054-M001
- Product descriptionMerck-5 ≥95%
- Packaging1mg
- Price$211
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1054-M005
- Product descriptionMerck-5 ≥95%
- Packaging5mg
- Price$524
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1054-M010
- Product descriptionMerck-5 ≥95%
- Packaging10mg
- Price$751
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1054-M100
- Product descriptionMerck-5 ≥95%
- Packaging100mg
- Price$3445
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1054
- Product descriptionMerck5
- Packaging5mg
- Price$505
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3741
- Product descriptionPyridone6
- Packaging5mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3741
- Product descriptionPyridone6
- Packaging10mM(in 1mL DMSO)
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3741
- Product descriptionPyridone6
- Packaging10mg
- Price$271
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3741
- Product descriptionPyridone6
- Packaging50mg
- Price$788
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3741
- Product descriptionPyridone6
- Packaging200mg
- Price$1809
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181055
- Product descriptionJAK Inhibitor I >98%
- Packaging100mg
- Price$1060.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181055
- Product descriptionJAK Inhibitor I >98%
- Packaging250mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181055
- Product descriptionJAK Inhibitor I >98%
- Packaging1000mg
- Price$3432.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15146
- Product descriptionJAK Inhibitor I ≥98%
- Packaging1mg
- Price$29
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15146
- Product descriptionJAK Inhibitor I ≥98%
- Packaging500μg
- Price$70
- Updated2023-06-20
- Buy
- ManufacturerCayman Chemical
- Product number15146
- Product descriptionJAK Inhibitor I ≥98%
- Packaging5mg
- Price$94
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1054-M001 | Merck-5 ≥95% | 1mg | $211 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1054-M005 | Merck-5 ≥95% | 5mg | $524 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1054-M010 | Merck-5 ≥95% | 10mg | $751 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1054-M100 | Merck-5 ≥95% | 100mg | $3445 | 2021-12-16 | Buy |
| AK Scientific | SYN1054 | Merck5 | 5mg | $505 | 2021-12-16 | Buy |
| ApexBio Technology | A3741 | Pyridone6 | 5mg | $197 | 2021-12-16 | Buy |
| ApexBio Technology | A3741 | Pyridone6 | 10mM(in 1mL DMSO) | $216 | 2021-12-16 | Buy |
| ApexBio Technology | A3741 | Pyridone6 | 10mg | $271 | 2021-12-16 | Buy |
| ApexBio Technology | A3741 | Pyridone6 | 50mg | $788 | 2021-12-16 | Buy |
| ApexBio Technology | A3741 | Pyridone6 | 200mg | $1809 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181055 | JAK Inhibitor I >98% | 100mg | $1060.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181055 | JAK Inhibitor I >98% | 250mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181055 | JAK Inhibitor I >98% | 1000mg | $3432.3 | 2021-12-16 | Buy |
| Cayman Chemical | 15146 | JAK Inhibitor I ≥98% | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 15146 | JAK Inhibitor I ≥98% | 500μg | $70 | 2023-06-20 | Buy |
| Cayman Chemical | 15146 | JAK Inhibitor I ≥98% | 5mg | $94 | 2024-03-01 | Buy |
Properties
Melting point :>178°C (dec.)
Boiling point :646.5±55.0 °C(Predicted)
Density :1.328
storage temp. :-20C
solubility :Soluble in DMSO (30 mg/ml)
form :Off-white solid
pka :11.35±0.20(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :646.5±55.0 °C(Predicted)
Density :1.328
storage temp. :-20C
solubility :Soluble in DMSO (30 mg/ml)
form :Off-white solid
pka :11.35±0.20(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-γ. JAK Inhibitor I is a pyridine-containing tetracycle that interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively, while displaying signi?cantly weaker affinities (IC50s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC50 values of 50-100 nM. In a mouse model of atopic dermatitis, JAK Inhibitor I, supplied at 2 mg encapsulated in a PLGA nanoparticle, was shown to suppress IFN-γ/STAT1, IL-2/STAT5, and IL-4/STAT6 signaling pathways.Related product price
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