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ChemicalBook >> CAS DataBase List >> IWP L6

IWP L6

IWP L6 price.
  • $65 - $2245.7
  • Product name: IWP L6
  • CAS: 1427782-89-5
  • MF: C25H20N4O2S2
  • MW: 472.58
  • EINECS:-0
  • MDL Number:MFCD27937771
  • Synonyms:IWP L6;2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide;Porcn Inhibitor III;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;IWP-L6, >=98%;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl
26 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50mg
  • 10
  • 50
  • 5mg
  • 10mg
  • 250mg
  • 10mM(in 1mL DMSO)
  • 100mg
  • 1000mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2487AH
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide
  • Packaging5mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2487AH
  • Product description2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2305
  • Product descriptionIWP-L6
  • Packaging10mg
  • Price$103
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2305
  • Product descriptionIWP-L6
  • Packaging10mM(in 1mL DMSO)
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2305
  • Product descriptionIWP-L6
  • Packaging50mg
  • Price$329
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2212
  • Product descriptionIWPL6 99%
  • Packaging10mg
  • Price$137.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181262
  • Product descriptionIWP-L6 >98%
  • Packaging100mg
  • Price$578
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181262
  • Product descriptionIWP-L6 >98%
  • Packaging250mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181262
  • Product descriptionIWP-L6 >98%
  • Packaging1000mg
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15243
  • Product descriptionIWP-L6 ≥98%
  • Packaging5mg
  • Price$82
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15243
  • Product descriptionIWP-L6 ≥98%
  • Packaging10mg
  • Price$153
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15243
  • Product descriptionIWP-L6 ≥98%
  • Packaging50mg
  • Price$561
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM151599
  • Product description2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 98%
  • Packaging50mg
  • Price$229
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2095
  • Product descriptionIWPL6 99.78%
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2095
  • Product descriptionIWPL6 99.78%
  • Packaging50mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2095
  • Product descriptionIWPL6 99.78%
  • Packaging100mg
  • Price$540
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2487AH 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 5mg $138 2021-12-16 Buy
AK Scientific 2487AH 2-((4-oxo-3-Phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 10mg $190 2021-12-16 Buy
ApexBio Technology B2305 IWP-L6 10mg $103 2021-12-16 Buy
ApexBio Technology B2305 IWP-L6 10mM(in 1mL DMSO) $130 2021-12-16 Buy
ApexBio Technology B2305 IWP-L6 50mg $329 2021-12-16 Buy
Axon Medchem Axon2212 IWPL6 99% 10mg $137.5 2021-12-16 Buy
Biorbyt Ltd orb181262 IWP-L6 >98% 100mg $578 2021-12-16 Buy
Biorbyt Ltd orb181262 IWP-L6 >98% 250mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb181262 IWP-L6 >98% 1000mg $2245.7 2021-12-16 Buy
Cayman Chemical 15243 IWP-L6 ≥98% 5mg $82 2024-03-01 Buy
Cayman Chemical 15243 IWP-L6 ≥98% 10mg $153 2024-03-01 Buy
Cayman Chemical 15243 IWP-L6 ≥98% 50mg $561 2024-03-01 Buy
Chemenu CM151599 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide 98% 50mg $229 2021-12-16 Buy
ChemScene CS-2095 IWPL6 99.78% 10mg $85 2021-12-16 Buy
ChemScene CS-2095 IWPL6 99.78% 50mg $300 2021-12-16 Buy
ChemScene CS-2095 IWPL6 99.78% 100mg $540 2021-12-16 Buy

Properties

storage temp. :Store at -20° C
solubility :≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM). It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats. In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation. It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.

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