GUGGULSTERONE E
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- $37 - $1055.09
- Product name: GUGGULSTERONE E
- CAS: 39025-24-6
- MF: C21H28O2
- MW: 312.45
- EINECS:
- MDL Number:MFCD01310758
- Synonyms:4,17(20)-(TRANS)-PREGNADIEN-3,16-DIONE;GS, TRANS;GUGGULESTERONE E;GUGGULSTERONE;GUGGULSTERONE E;GUGGULSTERONE (E FORM);TRANS-4,17(20)-PREGNADIENE-3,16-DIONE;TRANS-GUGGULSTERONE
11 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50MG
- ManufacturerAK Scientific
- Product numberF676
- Product description(E)-Guggulsterone
- Packaging10mg
- Price$433
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002873
- Product descriptionGUGGULSTERONE E 95.00%
- Packaging5MG
- Price$660.66
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002873
- Product descriptionGUGGULSTERONE E 95.00%
- Packaging10MG
- Price$698.54
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002873
- Product descriptionGUGGULSTERONE E 95.00%
- Packaging50MG
- Price$1055.09
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10011296
- Product description(E)-Guggulsterone
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10011296
- Product description(E)-Guggulsterone
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10011296
- Product description(E)-Guggulsterone
- Packaging10mg
- Price$301
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10011296
- Product description(E)-Guggulsterone
- Packaging25mg
- Price$704
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberG4923
- Product description(E)-Guggulsterone ≥95% (HPLC), powder
- Packaging5mg
- Price$68.4
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number68797
- Product description(E)-Guggulsterone analytical standard
- Packaging10mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberG852005
- Product description(E)-Guggulsterone
- Packaging50mg
- Price$835
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | F676 | (E)-Guggulsterone | 10mg | $433 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002873 | GUGGULSTERONE E 95.00% | 5MG | $660.66 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002873 | GUGGULSTERONE E 95.00% | 10MG | $698.54 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002873 | GUGGULSTERONE E 95.00% | 50MG | $1055.09 | 2021-12-16 | Buy |
| Cayman Chemical | 10011296 | (E)-Guggulsterone | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 10011296 | (E)-Guggulsterone | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 10011296 | (E)-Guggulsterone | 10mg | $301 | 2024-03-01 | Buy |
| Cayman Chemical | 10011296 | (E)-Guggulsterone | 25mg | $704 | 2024-03-01 | Buy |
| Sigma-Aldrich | G4923 | (E)-Guggulsterone ≥95% (HPLC), powder | 5mg | $68.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 68797 | (E)-Guggulsterone analytical standard | 10mg | $400 | 2021-12-16 | Buy |
| TRC | G852005 | (E)-Guggulsterone | 50mg | $835 | 2021-12-16 | Buy |
Properties
Melting point :170-171.5°
alpha :D26 -30° (c = 1 in chloroform)
Boiling point :463℃
Density :1.10
Flash point :172℃
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL
form :powder
color :white to off-white
LogP :3.650 (est)
alpha :D26 -30° (c = 1 in chloroform)
Boiling point :463℃
Density :1.10
Flash point :172℃
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL
form :powder
color :white to off-white
LogP :3.650 (est)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis. Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR both in vitro and in vivo. The cis stereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50 value of 15 M. By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.More related product prices
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