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ChemicalBook >> CAS DataBase List >> BIS(METHYLTHIO)GLIOTOXIN

BIS(METHYLTHIO)GLIOTOXIN

BIS(METHYLTHIO)GLIOTOXIN price.
  • $86 - $802
  • Product name: BIS(METHYLTHIO)GLIOTOXIN
  • CAS: 74149-38-5
  • MF: C15H20N2O4S2
  • MW: 356.46
  • EINECS:
  • MDL Number:MFCD00133146
  • Synonyms:gliotoxin, bis-dethio-bis(methylthio)-;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Bis(methylthio)gliotoxin (FR-49175);BIS(METHYLTHIO)GLIOTOXIN;FR-49175;bis-dethio-bis(methylthio)gliotoxin;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-
7 prices
Selected condition：
Brand
  • AK Scientific
  • Alfa Aesar
  • Cayman Chemical
  • Crysdot
  • TRC
Package
  • 500μg
  • 1mg
  • 2.5mg
  • 5mg
  • ManufacturerAK Scientific
  • Product number2418CB
  • Product descriptionBisdethiobis(methylthio)gliotoxin
  • Packaging1mg
  • Price$276
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67499
  • Product descriptionBis(methylthio)gliotoxin, 99%
  • Packaging1mg
  • Price$290
  • Updated2023-06-20
  • Buy
  • ManufacturerCayman Chemical
  • Product number26271
  • Product descriptionBis(methylthio)gliotoxin ≥95%
  • Packaging500μg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number26271
  • Product descriptionBis(methylthio)gliotoxin ≥95%
  • Packaging1mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD32000504
  • Product descriptionBis(methylthio)gliotoxin 95+%
  • Packaging5mg
  • Price$802
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB485948
  • Product descriptionBis(methylthio)gliotoxin(FR-49175)
  • Packaging1mg
  • Price$215
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB485948
  • Product descriptionBis(methylthio)gliotoxin(FR-49175)
  • Packaging2.5mg
  • Price$525
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2418CB Bisdethiobis(methylthio)gliotoxin 1mg $276 2021-12-16 Buy
Alfa Aesar J67499 Bis(methylthio)gliotoxin, 99% 1mg $290 2023-06-20 Buy
Cayman Chemical 26271 Bis(methylthio)gliotoxin ≥95% 500μg $86 2024-03-01 Buy
Cayman Chemical 26271 Bis(methylthio)gliotoxin ≥95% 1mg $161 2024-03-01 Buy
Crysdot CD32000504 Bis(methylthio)gliotoxin 95+% 5mg $802 2021-12-16 Buy
TRC B485948 Bis(methylthio)gliotoxin(FR-49175) 1mg $215 2021-12-16 Buy
TRC B485948 Bis(methylthio)gliotoxin(FR-49175) 2.5mg $525 2021-12-16 Buy

Properties

Boiling point :669.6±55.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
form :White solid.
pka :12.69±0.60(Predicted)
color :Off-White to Yellow
biological source :natural
Water Solubility :water: soluble

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P403 Store in a well-ventilated place.

Description

Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, reported to Inhibit PAF-induced bronchoconstriction.

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