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ChemicalBook >> CAS DataBase List >> Ascomycin

Ascomycin

Ascomycin price.
  • $30 - $800
  • Product name: Ascomycin
  • CAS: 104987-12-4
  • MF: C43H69NO12
  • MW: 792.01
  • EINECS:600-627-5
  • MDL Number:MFCD06198665
  • Synonyms:15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram;C058028;L 683590, FR 900520, IMMunoMycin, FK 520, WS 7238A, NSC 106410;Ascomycin:Tacrolimus Desmethylene Impurit;Tacrolimus USP RC A;FK-520;FR-900520;ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS
27 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Alfa Aesar
  • ApexBio Technology
  • Apolloscientific
  • AvaChem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 094-1ml
  • 2.5mg
  • 10mg
  • 1mL
  • 1g
  • 1
  • 1mg
  • 5mg
  • 25mg
  • 50mg
  • 100mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0420-M001
  • Product descriptionAscomycin(highpurity) ≥98%
  • Packaging1mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberL987
  • Product descriptionAscomycin
  • Packaging5mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ66751
  • Product descriptionAscomycin, 95%
  • Packaging25mg
  • Price$180
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ66751
  • Product descriptionAscomycin, 95%
  • Packaging100mg
  • Price$543
  • Updated2024-03-01
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3191
  • Product descriptionAscomycin(FK520)
  • Packaging50mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3191
  • Product descriptionAscomycin(FK520)
  • Packaging10mM(in 1mL DMSO)
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3191
  • Product descriptionAscomycin(FK520)
  • Packaging100mg
  • Price$78
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIA4317
  • Product descriptionAscomycin
  • Packaging25mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIA4317
  • Product descriptionAscomycin
  • Packaging50mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBIA4317
  • Product descriptionAscomycin
  • Packaging100mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2068
  • Product descriptionAscomycin
  • Packaging25mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11309
  • Product descriptionAscomycin ≥98%
  • Packaging5mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11309
  • Product descriptionAscomycin ≥98%
  • Packaging10mg
  • Price$92
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11309
  • Product descriptionAscomycin ≥98%
  • Packaging25mg
  • Price$146
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1516
  • Product descriptionAscomycin 99.62%
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1516
  • Product descriptionAscomycin 99.62%
  • Packaging50mg
  • Price$72
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0420-M001 Ascomycin(highpurity) ≥98% 1mg $30 2021-12-16 Buy
AK Scientific L987 Ascomycin 5mg $39 2021-12-16 Buy
Alfa Aesar J66751 Ascomycin, 95% 25mg $180 2024-03-01 Buy
Alfa Aesar J66751 Ascomycin, 95% 100mg $543 2024-03-01 Buy
ApexBio Technology A3191 Ascomycin(FK520) 50mg $60 2021-12-16 Buy
ApexBio Technology A3191 Ascomycin(FK520) 10mM(in 1mL DMSO) $65 2021-12-16 Buy
ApexBio Technology A3191 Ascomycin(FK520) 100mg $78 2021-12-16 Buy
Apolloscientific BIA4317 Ascomycin 25mg $45 2021-12-16 Buy
Apolloscientific BIA4317 Ascomycin 50mg $85 2021-12-16 Buy
Apolloscientific BIA4317 Ascomycin 100mg $135 2021-12-16 Buy
AvaChem 2068 Ascomycin 25mg $45 2021-12-16 Buy
Cayman Chemical 11309 Ascomycin ≥98% 5mg $49 2024-03-01 Buy
Cayman Chemical 11309 Ascomycin ≥98% 10mg $92 2024-03-01 Buy
Cayman Chemical 11309 Ascomycin ≥98% 25mg $146 2024-03-01 Buy
ChemScene CS-1516 Ascomycin 99.62% 10mg $60 2021-12-16 Buy
ChemScene CS-1516 Ascomycin 99.62% 50mg $72 2021-12-16 Buy

Properties

Melting point :153-157°C
Boiling point :868℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH
form :Powder
pka :9.97±0.70(Predicted)
color :White to off-white
Water Solubility :Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
InChIKey :ZDQSOHOQTUFQEM-AMASXYNMSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).

Description

Ascomycin, produced by the fermentation of S. hygroscopicus subsp. ascomyceticus, is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FK-506-binding protein 12 (FKBP12), an immunophilin that acts as the principal mediator of FK506- and rapamycin-induced immunosuppression. Ascomycin inhibits the enzymatic peptidyl-prolyl cis-trans isomerase and chaperone activities of PfFKBP35, an FKBP from P. falciparum, a causative agent of malaria in humans with an IC50 value of 0.52 μM.

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