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ChemicalBook >> CAS DataBase List >> Aprepitant

Aprepitant

Aprepitant price.
  • $5 - $3204
  • Product name: Aprepitant
  • CAS: 170729-80-3
  • MF: C23H21F7N4O3
  • MW: 534.43
  • EINECS:677-636-6
  • MDL Number:MFCD08277635
  • Synonyms:MK-0869;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend;Aprepitant(MK-0869);ONO 7436;5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholino)Methyl)-1H-1,2,4-triazol-3(2H)-one;Aprepirant;aprepitant
65 prices
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Brand
  • AccelPharmtech
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Ark Pharm
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
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  • 1g
  • 5g
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  • 25g
  • ManufacturerAccelPharmtech
  • Product numberLY1035
  • Product descriptionAprepitant 99.90%
  • Packaging10G
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ51364
  • Product descriptionAprepitant
  • Packaging1g
  • Price$121
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberL982
  • Product descriptionAprepitant
  • Packaging1g
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging25g
  • Price$668
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging5g
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging1g
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging250mg
  • Price$14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging100mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging50mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging10mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA103179
  • Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
  • Packaging5mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0000396
  • Product descriptionAPREPITANT 95.00%
  • Packaging5MG
  • Price$220
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1684
  • Product descriptionAprepitant
  • Packaging5mg
  • Price$69
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1684
  • Product descriptionAprepitant
  • Packaging10mM(in 1mL DMSO)
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1684
  • Product descriptionAprepitant
  • Packaging25mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1684
  • Product descriptionAprepitant
  • Packaging100mg
  • Price$428
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech LY1035 Aprepitant 99.90% 10G $320 2021-12-16 Buy
AK Scientific J51364 Aprepitant 1g $121 2021-12-16 Buy
AK Scientific L982 Aprepitant 1g $250 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 25g $668 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 5g $139 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 1g $37 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 250mg $14 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 100mg $11 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 50mg $9 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 10mg $7 2021-12-16 Buy
Ambeed A103179 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% 5mg $5 2021-12-16 Buy
American Custom Chemicals Corporation API0000396 APREPITANT 95.00% 5MG $220 2021-12-16 Buy
ApexBio Technology A1684 Aprepitant 5mg $69 2021-12-16 Buy
ApexBio Technology A1684 Aprepitant 10mM(in 1mL DMSO) $77 2021-12-16 Buy
ApexBio Technology A1684 Aprepitant 25mg $190 2021-12-16 Buy
ApexBio Technology A1684 Aprepitant 100mg $428 2021-12-16 Buy

Properties

Melting point :244-246°C
alpha :D25 +69° (c = 1.00 in methanol)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :8.06±0.20(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +61 to +71°, c = 1.0 in methanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :ATALOFNDEOCMKK-OITMNORJSA-N
SMILES :N1C(CN2CCO[C@H](O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)[C@@H]2C2=CC=C(F)C=C2)=NC(=O)N1
CAS DataBase Reference :170729-80-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Substance P, a neurokinin peptide found in the brain and gastrointestinal tract, is thought to modulate stress responses, including the emetic reflex. Its actions are mediated through the neurokinin-1 (NK1) receptor, one of three GPCRs that couple neurokinin binding to the inositol phosphate signal transduction pathway. Aprepitant is an anti-emetic compound that selectively antagonizes the human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively; IC50 = 0.09 nM for hNK1). In in vivo assays to measure peripheral (guinea pig SYVAL assay) and central (gerbil foot-tapping stress response assay) inhibition of NK1 receptors, aprepitant demonstrates ED50 values of 0.008 and 0.36 mg/kg, respectively. Through antagonism of NK1 receptor activity, aprepitant has found clinical use to prevent chemotherapy-induced nausea and vomiting.

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