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ChemicalBook >> CAS DataBase List >> (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide

(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide

(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide price.
  • $50 - $4230
  • Product name: (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide
  • CAS: 273404-37-8
  • MF: C24H33ClN4O6
  • MW: 508.99
  • EINECS:
  • MDL Number:MFCD11100350
  • Synonyms:(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide;Belnacasan (VX765);N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide;L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-;(S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrah;N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide VX 765;VX-765(Belnacasan);CS-387
33 prices
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Brand
  • AccelPharmtech
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Ark Pharm
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5MG
  • 10MG
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1G
  • ManufacturerAccelPharmtech
  • Product numberLX1651
  • Product description(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 98.00%
  • Packaging25MG
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0257
  • Product descriptionVX-765
  • Packaging50mg
  • Price$498
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0257
  • Product descriptionVX-765
  • Packaging250mg
  • Price$1501
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging1G
  • Price$4230
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging50MG
  • Price$613
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging10MG
  • Price$484
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging5MG
  • Price$460
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8238
  • Product descriptionVX-765
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8238
  • Product descriptionVX-765
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60139
  • Product descriptionBelnacasan(VX-765) ≥98%
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging50mg
  • Price$521
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging100mg
  • Price$852
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFV137735
  • Product descriptionVX 765
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech LX1651 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 98.00% 25MG $240 2021-12-16 Buy
AK Scientific Y0257 VX-765 50mg $498 2021-12-16 Buy
AK Scientific Y0257 VX-765 250mg $1501 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 1G $4230 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 50MG $613 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 10MG $484 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 5MG $460 2021-12-16 Buy
ApexBio Technology A8238 VX-765 10mg $100 2021-12-16 Buy
ApexBio Technology A8238 VX-765 100mg $450 2021-12-16 Buy
Arctom CFN60139 Belnacasan(VX-765) ≥98% 10mg $238 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 1mg $50 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 5mg $120 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 10mg $160 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 50mg $521 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 100mg $852 2021-12-16 Buy
Biosynth Carbosynth FV137735 VX 765 10mg $95 2021-12-16 Buy

Properties

Boiling point :779.0±60.0 °C(Predicted)
Density :1.32
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :12.60±0.40(Predicted)
color :Off-white to white
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Belnacasan (273404-37-8) is a prodrug of VRT-043198, a potent (Ki = 0.8 nM ICE/caspase-1; <0.6nM caspase-4) and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.1 VRT-043198 ICE/caspase-1 IC50 = 0.67 μM PBMCs, 1.0 μM whole blood.? It inhibited the release of IL-1b and IL-18 from human monocytes in vitro and their production in vivo in models of inflammation. Belnacasan inhibited the activation and expression of the NLRP3 Inflammasome leading to moderation of depressive-like behaviors induced by chronic mild stress2 and prevention of glial pyroptosis in multiple sclerosis models3. It inhibited pyroptosis in vascular smooth muscle cells during atherogenesis suggesting a possible therapeutic effect in treating atherosclerotic disease.4 Belnacasan reduced acute seizures and drug resistant chronic epileptic activity in mice5 and provided neuroprotection in two rat models of temporal lobe epilepsy6.? It also displays protective effects in models of stroke7and Alzheimer’s disease8.

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