2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
![2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE price.](/CAS/GIF/182004-65-5.gif)
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- $45 - $1853
- Product name: 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
- CAS: 182004-65-5
- MF: C17H21N3O6S2
- MW: 427.49
- EINECS:
- MDL Number:MFCD00952138
- Synonyms:Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate;Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate;KB-R7943;KB-R7943 MESYLATE;2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate;4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate
31 prices
Selected condition：
Brand
- AHH
- AK Scientific
- Ambeed
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chem-Impex
- ChemScene
- CSNpharm
- DC Chemicals
- Matrix Scientific
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 100mg
- 1g
- 1mg
- 0.05g
- 50
- 2.5mg
- 5mg
- 10mg
- 50mg
- 250mg
- 10mM(in 1mL DMSO)
- ManufacturerAHH
- Product numberMT-19776
- Product description2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate 95%
- Packaging0.05g
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0457
- Product description2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate
- Packaging250mg
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA722708
- Product descriptionKB-R7943Mesylate 95+%
- Packaging5mg
- Price$56
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA722708
- Product descriptionKB-R7943Mesylate 95+%
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA722708
- Product descriptionKB-R7943Mesylate 95+%
- Packaging50mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3525
- Product descriptionKB-R7943mesylate
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3525
- Product descriptionKB-R7943mesylate
- Packaging10mg
- Price$81
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3525
- Product descriptionKB-R7943mesylate
- Packaging50mg
- Price$285
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545845
- Product descriptionKb-R7943 mesylate >98%
- Packaging10mg
- Price$181.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545845
- Product descriptionKb-R7943 mesylate >98%
- Packaging50mg
- Price$489.6
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16352
- Product descriptionKB-R7943 (mesylate) ≥98%
- Packaging5mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16352
- Product descriptionKB-R7943 (mesylate) ≥98%
- Packaging10mg
- Price$77
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16352
- Product descriptionKB-R7943 (mesylate) ≥98%
- Packaging50mg
- Price$310
- Updated2024-03-01
- Buy
- ManufacturerChem-Impex
- Product number38111
- Product descriptionKB-R7943,98%(HPLC) 98%(HPLC)
- Packaging10MG
- Price$150.08
- Updated2021-12-16
- Buy
- ManufacturerChem-Impex
- Product number38111
- Product descriptionKB-R7943,98%(HPLC) 98%(HPLC)
- Packaging50MG
- Price$570.08
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0848
- Product descriptionKB-R7943mesylate 98.82%
- Packaging10mg
- Price$102
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | MT-19776 | 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate 95% | 0.05g | $370 | 2021-12-16 | Buy |
| AK Scientific | Y0457 | 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate | 250mg | $335 | 2021-12-16 | Buy |
| Ambeed | A722708 | KB-R7943Mesylate 95+% | 5mg | $56 | 2021-12-16 | Buy |
| Ambeed | A722708 | KB-R7943Mesylate 95+% | 10mg | $95 | 2021-12-16 | Buy |
| Ambeed | A722708 | KB-R7943Mesylate 95+% | 50mg | $240 | 2021-12-16 | Buy |
| ApexBio Technology | A3525 | KB-R7943mesylate | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3525 | KB-R7943mesylate | 10mg | $81 | 2021-12-16 | Buy |
| ApexBio Technology | A3525 | KB-R7943mesylate | 50mg | $285 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545845 | Kb-R7943 mesylate >98% | 10mg | $181.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545845 | Kb-R7943 mesylate >98% | 50mg | $489.6 | 2021-12-16 | Buy |
| Cayman Chemical | 16352 | KB-R7943 (mesylate) ≥98% | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 16352 | KB-R7943 (mesylate) ≥98% | 10mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 16352 | KB-R7943 (mesylate) ≥98% | 50mg | $310 | 2024-03-01 | Buy |
| Chem-Impex | 38111 | KB-R7943,98%(HPLC) 98%(HPLC) | 10MG | $150.08 | 2021-12-16 | Buy |
| Chem-Impex | 38111 | KB-R7943,98%(HPLC) 98%(HPLC) | 50MG | $570.08 | 2021-12-16 | Buy |
| ChemScene | CS-0848 | KB-R7943mesylate 98.82% | 10mg | $102 | 2021-12-16 | Buy |
Properties
Melting point :>214°C (dec.)
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :White crystalline solid
color :Tan
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :White crystalline solid
color :Tan
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The Na+/Ca2+ exchanger (NCX) is a major regulator of intracellular calcium concentration that is largely expressed in cardiac sarcolemma (NCX1) but also in brain and skeletal muscle (NCX2). KB-R7943 is an isothiourea derivative that selectively inhibits the reverse mode of NCX1 (IC50 = 1.2-2.4 μM), preventing intracellular sodium-dependent calcium uptake in whole cells. It is much less potent at preventing extracellular sodium-dependent calcium efflux from intact cells (IC50 > 30 μM). In cultured hippocampal neurons, KB-R7943 exhibits neuroprotection from glutamate-induced excitotoxicity by blocking NMDA receptor-mediated activity (IC50 = 13.4 μM) and inhibiting complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM). KB-R7943 has also been shown to block transient receptor potential canonical channels, which are important mediators of calcium-dependent signal transduction.Related product price
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![2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE](https://img.chemicalbook.com/ProductImageEN/2020-1/small/7ef85ae9-c56c-418c-a202-ae81fb168270.jpg){kind=small}
