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ChemicalBook >> CAS DataBase List >> 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy

1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy

1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy price.
  • $28 - $2700
  • Product name: 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
  • CAS: 145317-11-9
  • MF: C26H25ClN4O2
  • MW: 460.96
  • EINECS:
  • MDL Number:
  • Synonyms:1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy;1H-Pyrrole-2,5-dione,3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, (Hydrochloride) (1:1);Bisindoylmaleimide X HCl;BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE);Bisindoylmaleimide X hydrochloride ≥95%;3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;Bisindoylmaleimide X (Ro 31-8425);BIM X
23 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1021-M100
  • Product descriptionBisindoylmaleimideXhydrochloride ≥95%
  • Packaging100mg
  • Price$1366
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1021
  • Product descriptionBisindoylmaleimideXHCl
  • Packaging1mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1021
  • Product descriptionBisindoylmaleimideXHCl
  • Packaging100mg
  • Price$1285
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159144
  • Product description3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+%
  • Packaging1mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159144
  • Product description3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159144
  • Product description3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159144
  • Product description3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+%
  • Packaging25mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159144
  • Product description3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+%
  • Packaging50mg
  • Price$206
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159144
  • Product description3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+%
  • Packaging100mg
  • Price$308
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159144
  • Product description3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+%
  • Packaging250mg
  • Price$460
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000902
  • Product descriptionBISINDOLYLMALEIMIDEX HYDROCHLORIDE 95.00%
  • Packaging1MG
  • Price$643.72
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000902
  • Product descriptionBISINDOLYLMALEIMIDEX HYDROCHLORIDE 95.00%
  • Packaging5MG
  • Price$982.73
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17511
  • Product descriptionBisindolylmaleimide X (hydrochloride) ≥98%
  • Packaging1mg
  • Price$60
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17511
  • Product descriptionBisindolylmaleimide X (hydrochloride) ≥98%
  • Packaging5mg
  • Price$201
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0007416
  • Product descriptionBisindolylmaleimideX(hydrochloride) 98.53%
  • Packaging5mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0007416
  • Product descriptionBisindolylmaleimideX(hydrochloride) 98.53%
  • Packaging10mg
  • Price$250
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1021-M100 BisindoylmaleimideXhydrochloride ≥95% 100mg $1366 2021-12-16 Buy
AK Scientific SYN1021 BisindoylmaleimideXHCl 1mg $145 2021-12-16 Buy
AK Scientific SYN1021 BisindoylmaleimideXHCl 100mg $1285 2021-12-16 Buy
Ambeed A1159144 3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+% 1mg $28 2021-12-16 Buy
Ambeed A1159144 3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+% 5mg $60 2021-12-16 Buy
Ambeed A1159144 3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+% 10mg $90 2021-12-16 Buy
Ambeed A1159144 3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+% 25mg $138 2021-12-16 Buy
Ambeed A1159144 3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+% 50mg $206 2021-12-16 Buy
Ambeed A1159144 3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+% 100mg $308 2021-12-16 Buy
Ambeed A1159144 3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dionehydrochloride 98+% 250mg $460 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000902 BISINDOLYLMALEIMIDEX HYDROCHLORIDE 95.00% 1MG $643.72 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000902 BISINDOLYLMALEIMIDEX HYDROCHLORIDE 95.00% 5MG $982.73 2021-12-16 Buy
Cayman Chemical 17511 Bisindolylmaleimide X (hydrochloride) ≥98% 1mg $60 2024-03-01 Buy
Cayman Chemical 17511 Bisindolylmaleimide X (hydrochloride) ≥98% 5mg $201 2024-03-01 Buy
ChemScene CS-0007416 BisindolylmaleimideX(hydrochloride) 98.53% 5mg $145 2021-12-16 Buy
ChemScene CS-0007416 BisindolylmaleimideX(hydrochloride) 98.53% 10mg $250 2021-12-16 Buy

Properties

storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :Soluble in DMSO (up to 10 mg/ml)
form :Red solid.
color :Red
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). It has been shown to inhibit PKCα, βI, βII, γ, and ε with IC50 values of 8, 8, 14, 13, and 39 nM, respectively. It has also been identified as an inhibitor of Cdk2 (IC50 = 200 nM) and GSK3α/β. This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule 1, and target delivery of these cells to sites of inflammation.

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