GNE 7915 suppliers
GNE 7915
- CAS:
- 1351761-44-8
- MF:
- C19H21F4N5O3
- MW:
- 443.4
Suppliers by country/region
Company Type
Properties
- Melting point:
- 143 - 144°C
- Boiling point:
- 629.9±65.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- solid
- pka
- 2.80±0.10(Predicted)
- color
- Off-white to light yellow
- CAS DataBase Reference
- 1351761-44-8
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Use
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]
72 supplier list of "GNE 7915"
- Product Name:GNE-7915
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:GNE-7915
- Products Intro:Package: 100mg | CustNote: BOC Sciences also provides custom synthesis services for GNE-7915.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:GNE-7915；GNE7915
- Products Intro:Purity: >=95% | Package: 10mg;34USD|25mg;70USD|50mg;118USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:GNE 7915
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:GNE 7915
- Products Intro:Purity: 99% | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Peptide Chemical,Heterocyclic compound,Organoboron Compound,Linker
- Product Name:GNE-7915
- Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediate
- Product Name:GNE 7915
- Products Intro:Purity: 0.95_) | Package: 10G;50G;100G | CustNote: Chemically Pure
- Company Type: Trader
- Country/Region: CHINA
- Product Name:GNE7915
- Products Intro:Purity: 98% | Package: $48.9/5mg;$69.9/10mg;$140.9/25mg;$235.9/50mg;$400.9/100mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:GNE 7915
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A858153
- Company Type: Reagent
- Country/Region: CHINA