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ChemicalBook CAS DataBase List THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
59944-76-2

THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID synthesis

4synthesis methods
-

Yield:59944-76-2 85%

Reaction Conditions:

with hydrogenchloride;sodium hydroxide in methanol;water;

Steps:

12.v N-(1-azabicyclo[2.2.1]hept-3-yl)-thieno[2,3-b]pyridine-2-carboxamide

C101 (0.700 g, 3.63 mmol) is dissolved in MeOH (15 mL) and 3 mL H2O. 2N NaOH (1.82 mL, 3.63 mmol) is added drop-wise, and the reaction is stirred at rt for 24 h. The reaction is concentrated in vacuo, and H2O (40 mL) is added to dissolve the residue. The resulting solution is acidified to pH 4 using concentrated HCl, and the precipitate is isolated by filtration, yielding thieno[2,3-b]pyridine-2-carboxylic acid (C102) as a white powder (85% yield). MS (EI) for C8H5NO2S, M/z: 179 (M)+.

References:

US2003/153595,2003,A1

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