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PPQ-102

化學(xué)構(gòu)造式
931706-15-9
CAS番號(hào).
931706-15-9
化學(xué)名:
別名:
英語名:
PPQ-102
英語別名:
PPQ-102;CS-1365;CFTR Inhibitor;PPQ 102, >=98%;PPQ-102, CFTR Inhibitor;CFTR INHIBITOR; PPQ102; PPQ 102;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem;7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
CBNumber:
CB82628279
化學(xué)式:
C26H22N4O3
分子量:
438.48
MOL File:
931706-15-9.mol
MSDS File:
SDS

PPQ-102 物理性質(zhì)

融點(diǎn) :
>300℃ (ethanol )
沸點(diǎn) :
648.7±65.0 °C(Predicted)
比重(密度) :
1.39±0.1 g/cm3(Predicted)
貯蔵溫度 :
-20C
溶解性:
DMF: 0.2 mg/ml
外見 :
白色結(jié)晶性固體
酸解離定數(shù)(Pka):
1.00±0.40(Predicted)
色:
Light yellow to yellow
安全性情報(bào)
  • リスクと安全性に関する聲明
  • 危険有害性情報(bào)のコード(GHS)
絵表示（GHS） GHS hazard pictograms
注意喚起語 警告
危険有害性情報(bào)
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
注意書き
P280 保護(hù)手袋/保護(hù)衣/保護(hù)眼鏡/保護(hù)面を著用するこ と。
P305+P351+P338 眼に入った場合：水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

PPQ-102 価格 もっと(8)

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購入
富士フイルム和光純薬株式會(huì)社(wako) W01COBQJ-2415
Ppq-102 		931706-15-9 250mg ￥165000 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01COBQJ-2415
Ppq-102 		931706-15-9 1g ￥440000 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01CAY16275
PPQ-102 		931706-15-9 5mg ￥25200 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01CAY16275
PPQ-102 		931706-15-9 10mg ￥47900 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01TOC4303
PPQ 102 		931706-15-9 10mg ￥61000 2024-03-01 購入

PPQ-102 化學(xué)特性,用途語,生産方法

一般的な説明

A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture.

PPQ-102 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品

PPQ-102 生産企業(yè)

Global( 77)Suppliers
名前 電話番號(hào) 電子メール 國籍 製品カタログ 優(yōu)位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
Haoyuan Chemexpress Co., Ltd. 021-58950125
info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58
AdooQ Bioscience CHINA 025-58849295 18951903616;
 info@adooq.cn China 2990 60

931706-15-9()キーワード:

  • 931706-15-9
  • PPQ-102
  • 7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE
  • PPQ-102, CFTR Inhibitor
  • 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
  • 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quin
  • 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione PPQ-102
  • PPQ-102 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
  • PPQ 102, >=98%
  • CS-1365
  • CFTR Inhibitor
  • CFTR INHIBITOR; PPQ102; PPQ 102
  • CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem
  • Pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione, 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-
  • 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione
  • polycystic kidney disease,E13.5 embryonic kidneys,inhibit,Inhibitor,PPQ-102,CFTR,Cystic fibrosis transmembrane conductance regulator
  • 7,9-Dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione
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