4-メトキシフェノール 化學(xué)特性,用途語,生産方法
外観
白色～わずかにうすい黃色, 結(jié)晶～結(jié)晶性粉末
定義
本品は、フェノール(*)の誘導(dǎo)體であり、次の化學(xué)式で表される。
參照表示名稱：フェノール
溶解性
水に微溶 (4g/100ml 25℃).エタノール, エーテルに易溶。エタノール及びアセトンに溶けやすく、水に溶けにくい。
用途
有機(jī)合成原料、安定剤(重合禁止剤)。1. アクリル酸エステル、アクリルニトリルモノマーの重合防止剤 添加量は10～500ppm。2. 油脂、脂肪酸、石けん等の酸化防止剤。3. エチルセルロースへの0.5～3%添加により粘度、柔軟性等の保持に効果。
用途
重合防止剤、香料、プラスチック添加剤
化粧品の成分用途
還元剤、酸化防止剤、香料
効能
色素沈著改善薬
化學(xué)的特性
4-Methoxyphenol is a colorless to white, waxy solid with an odor of caramel and phenol. It is a combustible solid. It is used as an inhibitor for acrylic monomers and as a stabilizer for chlorinated hydrocarbons, ethyl cellulose, and UV inhibitors.
適応癥
Mequinol (4-hydroxyanisole) is a substrate of the enzyme tyrosinase and acts
as a competitive inhibitor of melanogenesis.
合成
4-Methoxyphenol was synthesised according to Oxidation with H2O2 and a Diselenide catalyst.
p-Anisaldehyde (50 mmol) is dissolved in CH2Cl2 (100mL) and (o-NO2PhSe)2 (2 mmol) and 30% H2O2 (13mL, 128 mmol) are added. The mixture is stirred magnetically at room temperature (water bath) for 30 minutes. Insoluble catalyst is removed by filtration and washed with CH2Cl2 (20mL) and water (20mL). It can be reused after drying. To the filtrate and washings, water (100mL) is added, and the layers are separated after shaking. The organic layer is washed subsequently with 10% NaHSO3 (100mL), 10% Na2CO3 (100mL), water (100mL) and dried over Na2SO4. 4-methoxyphenol is obtained by alkaline hydrolysis of the residue. Yield: 93%.
反応性
4-methoxyphenol(4-MP) may be used in the synthesis of butylated hydroxy anisoles via alkylation with methyl tert-butyl ether over a non-zeolitic solid acidic catalyst. This process is eco-friendly when compared to the Friedel-Crafts alkylation reaction. 4-MP may also react with aqueous nitrous acid to form 2-nitro-4-methoxyphenol and benzoquinone in varying ratios depending on the reaction conditions. 4-MP can be used as a building block in designing β-cyclodextrin 4-methoxyphenol conjugates that can be potential ligands for drug complexation.
一般的な説明
Pink crystals or white waxy solid.
空気と水の反応
Sensitive to moisture. Water soluble.
反応プロフィール
4-Methoxyphenol can react with oxidizing materials.
危険性
Eye irritant and skin damage.
健康ハザード
4-Methoxyphenol is expected to
cause liver and renal toxicity with narcosis, but
only at high levels of exposure.
火災(zāi)危険
Combustible
安全性プロファイル
Poison by
intraperitoneal route. A skin irritant. When
heated to decomposition it emits acrid
smoke and fumes. See also ETHERS.
輸送方法
UN3335 Aviation regulated solid, n.o.s., Hazard
class: 9; Labels: 9-Miscellaneous hazardous material,
Technical Name Required.
純化方法
Crystallise 4-methoxyphenol from *benzene, pet ether or H2O, and dry it under vacuum over P2O5 at room temperature. Sublime it in vacuo. [Wolfenden et al. J Am Chem Soc 109 463 1987, Beilstein 6 IV 5717.]
4-メトキシフェノール 上流と下流の製品情報
原材料
準(zhǔn)備製品