チモペンチン
チモペンチン 物理性質(zhì)
- 比重(密度) :
- 1.44±0.1 g/cm3(Predicted)
- 貯蔵溫度 :
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 溶解性:
- DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
- 外見(jiàn) :
- 粉
- 酸解離定數(shù)(Pka):
- 3.07±0.10(Predicted)
- 色:
- 白い
- CAS データベース:
- 69558-55-0(CAS DataBase Reference)
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
| WGK Germany |
3 |
|
|
| HSコード |
3504009000 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語(yǔ) |
警告 |
| 危険有害性情報(bào) |
| コード |
危険有害性情報(bào) |
危険有害性クラス |
區(qū)分 |
注意喚起語(yǔ) |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書(shū)き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時(shí)に、飲食または喫煙をしないこ と。 |
| P301+P312 |
飲み込んだ場(chǎng)合：気分が悪い時(shí)は醫(yī)師に連絡(luò)する こと。 |
| P330 |
口をすすぐこと。 |
| P501 |
內(nèi)容物/容器を．．．に廃棄すること。 |
|
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTT3093 |
チモペンチン
Thymopentin |
69558-55-0 |
5mg |
￥47400 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTT3093 |
チモペンチン
Thymopentin |
69558-55-0 |
10mg |
￥80600 |
2024-03-01 |
購(gòu)入 |
|
Sigma-Aldrich Japan
|
T8806 |
≥97% (HPLC)
Thymopentin ≥97% (HPLC) |
69558-55-0 |
10mg |
￥25500 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTT3094 |
酢酸チモペンチン
Thymopentin Acetate |
69558-55-0 |
10mg |
￥26600 |
2024-03-01 |
購(gòu)入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01LKTT3094 |
酢酸チモペンチン
Thymopentin Acetate |
69558-55-0 |
50mg |
￥115100 |
2024-03-01 |
購(gòu)入 |
チモペンチン 化學(xué)特性,用途語(yǔ),生産方法
効能
免疫賦活薬
説明
Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.
使用
Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.
臨床応用
Thymopentin is a synthetic, immunomodulating pentapeptide, representing the
active fragment of the thymus hormone, thymopoietin. Thymopentin induces
phenotypic differentiation and maturation of T-cells. It appears of value in the
treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis,
sarcoidosis and a variety of other diseases with manifestations of disturbed
immune balance.
參考文獻(xiàn)
Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.
チモペンチン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
チモペンチン 生産企業(yè)
Global( 427)Suppliers
69558-55-0(チモペンチン)キーワード:
- 69558-55-0
- 32-36-Thymopoietin
- L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH
- Thymopoietin II-(32-36)
- ThyMopentin for Injection
- TP-5
- THYMOPENTIN
- THYMOPENTIN 5
- THYMOPOIETIN (32-36) (HUMAN, MOUSE)
- THYMOPOIETIN II FRAGMENT (32-36)
- THYMOPOIETIN I/II (32-36) (BOVINE)
- THYMOPOIETIN PENTAPEPTIDE
- Immunox
- Sintomodulina
- Thymopentin-FITC
- Thymopoietin 32-36
- Timunox
- ARG-LYS-ASP-VAL-TYR
- (ASP34)-THYMOPOIETIN III (32-36) (BOVINE)
- H-ARG-LYS-ASP-VAL-TYR-OH
- RKDVY
- TP-5（Thymopentin）
- Thymopentin TP-5
- Thymopentine
- THYMOPETIN
- Arg-Lys-Asp-Val-Tyr-OH
- Thymopoietin pentapeptide-Fluorescin-isothiocyanate
- thymopentin pentapeptide
- Thyopentin
- Thymopent njection
- ThymopentinⅡ
- チモポイエチンペンタペプチド
- チモペンチン
- 32-36-チモポイエチン
- N-[N-[N-(N2-L-アルギニル-L-リシル)-L-α-アスパルチル]-L-バリル]-L-チロシン
- チモポイエチンII(32-36)
- チモポイエチンII-(32-36)
- 酢酸チモペンチン
- (3S)-3-[(2S)-6-アミノ-2-[(2S)-2-アミノ-5-カルバムイミドアミドペンタンアミド]ヘキサンアミド]-3-{[(1S)-1-{[(1S)-1-カルボキシ-2-(4-ヒドロキシフェニル)エチル]カルバモイル}-2-メチルプロピル]カルバモイル}プロパン酸
- ペプチドホルモン
- 胸腺ホルモン